Atherosclerotic Plaque Tissue Characterization: An OCT-Based Machine Learning Algorithm With ex vivo Validation

There is a need to develop a validated algorithm for plaque characterization which can help to facilitate the standardization of optical coherence tomography (OCT) image interpretation of plaque morphology, and improve the efficiency and accuracy in the application of OCT imaging for the quantitative assessment of plaque vulnerability. In this study, a machine learning algorithm was implemented for characterization of atherosclerotic plaque components by intravascular OCT using ex vivo carotid plaque tissue samples. A total of 31 patients underwent carotid endarterectomy and the ex vivo carotid plaques were imaged with OCT. Optical parameter, texture features and relative position of pixels were extracted within the region of interest and then used to quantify the tissue characterization of plaque components. The potential of individual and combined feature set to discriminate tissue components was quantified using sensitivity, specificity, accuracy. The results show there was a lower classification accuracy in the calcified tissue than the fibrous tissue and lipid tissue. The pixel-wise classification accuracy obtained by the developed method, to characterize the fibrous, calcified and lipid tissue by comparing with histology, were 80.0, 62.0, and 83.1, respectively. The developed algorithm was capable of characterizing plaque components with an excellent accuracy using the combined feature set.