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Dysphagia in cervical dystonia patients receiving optimised botulinum toxin therapy: a single-center retrospective cohort study

To explore the correlations of botulinum toxin (BT) therapy with dysphagia, we wanted to study a group of cervical dystonia (CD) patients with optimised BT therapy during a prolonged period of time to record their dysphagia frequency, severity and duration, to study potential risk factors and try to...

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Autores principales: Kutschenko, Anna, Klietz, Martin, Paracka, Lejla, Kollewe, Katja, Schulte-Sutum, Annika, Janssen, Theda, Schrader, Christoph, Wegner, Florian, Dressler, Dirk
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Vienna 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7343731/
https://www.ncbi.nlm.nih.gov/pubmed/32588245
http://dx.doi.org/10.1007/s00702-020-02220-z
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author Kutschenko, Anna
Klietz, Martin
Paracka, Lejla
Kollewe, Katja
Schulte-Sutum, Annika
Janssen, Theda
Schrader, Christoph
Wegner, Florian
Dressler, Dirk
author_facet Kutschenko, Anna
Klietz, Martin
Paracka, Lejla
Kollewe, Katja
Schulte-Sutum, Annika
Janssen, Theda
Schrader, Christoph
Wegner, Florian
Dressler, Dirk
author_sort Kutschenko, Anna
collection PubMed
description To explore the correlations of botulinum toxin (BT) therapy with dysphagia, we wanted to study a group of cervical dystonia (CD) patients with optimised BT therapy during a prolonged period of time to record their dysphagia frequency, severity and duration, to study potential risk factors and try to avoid it by BT application with ultrasound guidance. BT therapy of 75 CD patients (23 males, 52 females, age 60 ± 12 years, BT total dose 303.5 ± 101.5 uMU) was retrospectively analysed for 1 year. BT therapy was optimised prior to the observation period. Dysphagia was noticed by one fifth of the patients. In those patients, it only occurred in about one third of the injection series. It was never associated with a functional deficit and lasted several days to 2 weeks. It was not related to patient age or gender, BT total dose, BT dose in the sternocleidomastoid muscle, BT dose in the sternocleidomastoid and scalenii muscles, by BT therapy with bilateral sternocleidomastoid muscle injections or BT therapy with abobotulinumtoxinA. Ultrasound guidance was not able to prevent it. Further prospective studies will be necessary to study underlying dystonia associated swallowing abnormalities as a potentially predisposing factor.
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spelling pubmed-73437312020-07-13 Dysphagia in cervical dystonia patients receiving optimised botulinum toxin therapy: a single-center retrospective cohort study Kutschenko, Anna Klietz, Martin Paracka, Lejla Kollewe, Katja Schulte-Sutum, Annika Janssen, Theda Schrader, Christoph Wegner, Florian Dressler, Dirk J Neural Transm (Vienna) Neurology and Preclinical Neurological Studies - Original Article To explore the correlations of botulinum toxin (BT) therapy with dysphagia, we wanted to study a group of cervical dystonia (CD) patients with optimised BT therapy during a prolonged period of time to record their dysphagia frequency, severity and duration, to study potential risk factors and try to avoid it by BT application with ultrasound guidance. BT therapy of 75 CD patients (23 males, 52 females, age 60 ± 12 years, BT total dose 303.5 ± 101.5 uMU) was retrospectively analysed for 1 year. BT therapy was optimised prior to the observation period. Dysphagia was noticed by one fifth of the patients. In those patients, it only occurred in about one third of the injection series. It was never associated with a functional deficit and lasted several days to 2 weeks. It was not related to patient age or gender, BT total dose, BT dose in the sternocleidomastoid muscle, BT dose in the sternocleidomastoid and scalenii muscles, by BT therapy with bilateral sternocleidomastoid muscle injections or BT therapy with abobotulinumtoxinA. Ultrasound guidance was not able to prevent it. Further prospective studies will be necessary to study underlying dystonia associated swallowing abnormalities as a potentially predisposing factor. Springer Vienna 2020-06-25 2020 /pmc/articles/PMC7343731/ /pubmed/32588245 http://dx.doi.org/10.1007/s00702-020-02220-z Text en © The Author(s) 2020 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Neurology and Preclinical Neurological Studies - Original Article
Kutschenko, Anna
Klietz, Martin
Paracka, Lejla
Kollewe, Katja
Schulte-Sutum, Annika
Janssen, Theda
Schrader, Christoph
Wegner, Florian
Dressler, Dirk
Dysphagia in cervical dystonia patients receiving optimised botulinum toxin therapy: a single-center retrospective cohort study
title Dysphagia in cervical dystonia patients receiving optimised botulinum toxin therapy: a single-center retrospective cohort study
title_full Dysphagia in cervical dystonia patients receiving optimised botulinum toxin therapy: a single-center retrospective cohort study
title_fullStr Dysphagia in cervical dystonia patients receiving optimised botulinum toxin therapy: a single-center retrospective cohort study
title_full_unstemmed Dysphagia in cervical dystonia patients receiving optimised botulinum toxin therapy: a single-center retrospective cohort study
title_short Dysphagia in cervical dystonia patients receiving optimised botulinum toxin therapy: a single-center retrospective cohort study
title_sort dysphagia in cervical dystonia patients receiving optimised botulinum toxin therapy: a single-center retrospective cohort study
topic Neurology and Preclinical Neurological Studies - Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7343731/
https://www.ncbi.nlm.nih.gov/pubmed/32588245
http://dx.doi.org/10.1007/s00702-020-02220-z
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