In vitro and In vivo Assessment of Suitable Reference Region and Kinetic Modelling for the mGluR1 Radioligand [(11)C]ITDM in Mice

PURPOSE: This study aimed at investigating binding specificity, suitability of reference region-based kinetic modelling, and pharmacokinetics of the metabotropic glutamate receptor 1 (mGluR1) radioligand [(11)C]ITDM in mice. PROCEDURES: We performed in vivo blocking as well as displacement of [(11)C...

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Detalles Bibliográficos
Autores principales: Bertoglio, Daniele, Verhaeghe, Jeroen, Korat, Špela, Miranda, Alan, wyffels, Leonie, Stroobants, Sigrid, Mrzljak, Ladislav, Dominguez, Celia, Liu, Longbin, Skinbjerg, Mette, Munoz-Sanjuan, Ignacio, Staelens, Steven
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7343737/
https://www.ncbi.nlm.nih.gov/pubmed/31792838
http://dx.doi.org/10.1007/s11307-019-01435-1

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