Current Insights in Cutaneous Lupus Erythematosus Immunopathogenesis

Cutaneous Lupus Erythematosus (CLE) is a clinically diverse group of autoimmune skin diseases with shared histological features of interface dermatitis and autoantibodies deposited at the dermal–epidermal junction. Various genetic and environmental triggers of CLE promote infiltration of T cells, B...

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Autores principales: Garelli, Colton J., Refat, Maggi Ahmed, Nanaware, Padma P., Ramirez-Ortiz, Zaida G., Rashighi, Mehdi, Richmond, Jillian M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7343764/
https://www.ncbi.nlm.nih.gov/pubmed/32714331
http://dx.doi.org/10.3389/fimmu.2020.01353
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author Garelli, Colton J.
Refat, Maggi Ahmed
Nanaware, Padma P.
Ramirez-Ortiz, Zaida G.
Rashighi, Mehdi
Richmond, Jillian M.
author_facet Garelli, Colton J.
Refat, Maggi Ahmed
Nanaware, Padma P.
Ramirez-Ortiz, Zaida G.
Rashighi, Mehdi
Richmond, Jillian M.
author_sort Garelli, Colton J.
collection PubMed
description Cutaneous Lupus Erythematosus (CLE) is a clinically diverse group of autoimmune skin diseases with shared histological features of interface dermatitis and autoantibodies deposited at the dermal–epidermal junction. Various genetic and environmental triggers of CLE promote infiltration of T cells, B cells, neutrophils, antigen presenting cells, and NK cells into lesional skin. In this mini-review, we will discuss the clinical features of CLE, insights into CLE immunopathogenesis, and novel treatment approaches.
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spelling pubmed-73437642020-07-25 Current Insights in Cutaneous Lupus Erythematosus Immunopathogenesis Garelli, Colton J. Refat, Maggi Ahmed Nanaware, Padma P. Ramirez-Ortiz, Zaida G. Rashighi, Mehdi Richmond, Jillian M. Front Immunol Immunology Cutaneous Lupus Erythematosus (CLE) is a clinically diverse group of autoimmune skin diseases with shared histological features of interface dermatitis and autoantibodies deposited at the dermal–epidermal junction. Various genetic and environmental triggers of CLE promote infiltration of T cells, B cells, neutrophils, antigen presenting cells, and NK cells into lesional skin. In this mini-review, we will discuss the clinical features of CLE, insights into CLE immunopathogenesis, and novel treatment approaches. Frontiers Media S.A. 2020-07-02 /pmc/articles/PMC7343764/ /pubmed/32714331 http://dx.doi.org/10.3389/fimmu.2020.01353 Text en Copyright © 2020 Garelli, Refat, Nanaware, Ramirez-Ortiz, Rashighi and Richmond. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Garelli, Colton J.
Refat, Maggi Ahmed
Nanaware, Padma P.
Ramirez-Ortiz, Zaida G.
Rashighi, Mehdi
Richmond, Jillian M.
Current Insights in Cutaneous Lupus Erythematosus Immunopathogenesis
title Current Insights in Cutaneous Lupus Erythematosus Immunopathogenesis
title_full Current Insights in Cutaneous Lupus Erythematosus Immunopathogenesis
title_fullStr Current Insights in Cutaneous Lupus Erythematosus Immunopathogenesis
title_full_unstemmed Current Insights in Cutaneous Lupus Erythematosus Immunopathogenesis
title_short Current Insights in Cutaneous Lupus Erythematosus Immunopathogenesis
title_sort current insights in cutaneous lupus erythematosus immunopathogenesis
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7343764/
https://www.ncbi.nlm.nih.gov/pubmed/32714331
http://dx.doi.org/10.3389/fimmu.2020.01353
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