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SARS-CoV-2 is transmitted via contact and via the air between ferrets

SARS-CoV-2, a coronavirus that emerged in late 2019, has spread rapidly worldwide, and information about the modes of transmission of SARS-CoV-2 among humans is critical to apply appropriate infection control measures and to slow its spread. Here we show that SARS-CoV-2 is transmitted efficiently vi...

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Autores principales: Richard, Mathilde, Kok, Adinda, de Meulder, Dennis, Bestebroer, Theo M., Lamers, Mart M., Okba, Nisreen M. A., Fentener van Vlissingen, Martje, Rockx, Barry, Haagmans, Bart L., Koopmans, Marion P. G., Fouchier, Ron A. M., Herfst, Sander
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7343828/
https://www.ncbi.nlm.nih.gov/pubmed/32641684
http://dx.doi.org/10.1038/s41467-020-17367-2
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author Richard, Mathilde
Kok, Adinda
de Meulder, Dennis
Bestebroer, Theo M.
Lamers, Mart M.
Okba, Nisreen M. A.
Fentener van Vlissingen, Martje
Rockx, Barry
Haagmans, Bart L.
Koopmans, Marion P. G.
Fouchier, Ron A. M.
Herfst, Sander
author_facet Richard, Mathilde
Kok, Adinda
de Meulder, Dennis
Bestebroer, Theo M.
Lamers, Mart M.
Okba, Nisreen M. A.
Fentener van Vlissingen, Martje
Rockx, Barry
Haagmans, Bart L.
Koopmans, Marion P. G.
Fouchier, Ron A. M.
Herfst, Sander
author_sort Richard, Mathilde
collection PubMed
description SARS-CoV-2, a coronavirus that emerged in late 2019, has spread rapidly worldwide, and information about the modes of transmission of SARS-CoV-2 among humans is critical to apply appropriate infection control measures and to slow its spread. Here we show that SARS-CoV-2 is transmitted efficiently via direct contact and via the air (via respiratory droplets and/or aerosols) between ferrets, 1 to 3 days and 3 to 7 days after exposure respectively. The pattern of virus shedding in the direct contact and indirect recipient ferrets is similar to that of the inoculated ferrets and infectious virus is isolated from all positive animals, showing that ferrets are productively infected via either route. This study provides experimental evidence of robust transmission of SARS-CoV-2 via the air, supporting the implementation of community-level social distancing measures currently applied in many countries in the world and informing decisions on infection control measures in healthcare settings.
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spelling pubmed-73438282020-07-13 SARS-CoV-2 is transmitted via contact and via the air between ferrets Richard, Mathilde Kok, Adinda de Meulder, Dennis Bestebroer, Theo M. Lamers, Mart M. Okba, Nisreen M. A. Fentener van Vlissingen, Martje Rockx, Barry Haagmans, Bart L. Koopmans, Marion P. G. Fouchier, Ron A. M. Herfst, Sander Nat Commun Article SARS-CoV-2, a coronavirus that emerged in late 2019, has spread rapidly worldwide, and information about the modes of transmission of SARS-CoV-2 among humans is critical to apply appropriate infection control measures and to slow its spread. Here we show that SARS-CoV-2 is transmitted efficiently via direct contact and via the air (via respiratory droplets and/or aerosols) between ferrets, 1 to 3 days and 3 to 7 days after exposure respectively. The pattern of virus shedding in the direct contact and indirect recipient ferrets is similar to that of the inoculated ferrets and infectious virus is isolated from all positive animals, showing that ferrets are productively infected via either route. This study provides experimental evidence of robust transmission of SARS-CoV-2 via the air, supporting the implementation of community-level social distancing measures currently applied in many countries in the world and informing decisions on infection control measures in healthcare settings. Nature Publishing Group UK 2020-07-08 /pmc/articles/PMC7343828/ /pubmed/32641684 http://dx.doi.org/10.1038/s41467-020-17367-2 Text en © The Author(s) 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Richard, Mathilde
Kok, Adinda
de Meulder, Dennis
Bestebroer, Theo M.
Lamers, Mart M.
Okba, Nisreen M. A.
Fentener van Vlissingen, Martje
Rockx, Barry
Haagmans, Bart L.
Koopmans, Marion P. G.
Fouchier, Ron A. M.
Herfst, Sander
SARS-CoV-2 is transmitted via contact and via the air between ferrets
title SARS-CoV-2 is transmitted via contact and via the air between ferrets
title_full SARS-CoV-2 is transmitted via contact and via the air between ferrets
title_fullStr SARS-CoV-2 is transmitted via contact and via the air between ferrets
title_full_unstemmed SARS-CoV-2 is transmitted via contact and via the air between ferrets
title_short SARS-CoV-2 is transmitted via contact and via the air between ferrets
title_sort sars-cov-2 is transmitted via contact and via the air between ferrets
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7343828/
https://www.ncbi.nlm.nih.gov/pubmed/32641684
http://dx.doi.org/10.1038/s41467-020-17367-2
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