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κB-Ras and Ral GTPases regulate acinar to ductal metaplasia during pancreatic adenocarcinoma development and pancreatitis

Pancreatic ductal adenocarcinoma (PDAC) is associated with high mortality and therapy resistance. Here, we show that low expression of κB-Ras GTPases is frequently detected in PDAC and correlates with higher histologic grade. In a model of KRas(G12D)-driven PDAC, loss of κB-Ras accelerates tumour de...

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Detalles Bibliográficos
Autores principales:	Beel, Stephanie, Kolloch, Lina, Apken, Lisa H., Jürgens, Lara, Bolle, Andrea, Sudhof, Nadine, Ghosh, Sankar, Wardelmann, Eva, Meisterernst, Michael, Steinestel, Konrad, Oeckinghaus, Andrea
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7343838/ https://www.ncbi.nlm.nih.gov/pubmed/32641778 http://dx.doi.org/10.1038/s41467-020-17226-0

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