Absence of central tolerance in Aire-deficient mice synergizes with immune-checkpoint inhibition to enhance antitumor responses

The endogenous anti-tumor responses are limited in part by the absence of tumor-reactive T cells, an inevitable consequence of thymic central tolerance mechanisms ensuring prevention of autoimmunity. Here we show that tumor rejection induced by immune checkpoint blockade is significantly enhanced in...

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Detalles Bibliográficos
Autores principales: Benitez, Asiel A., Khalil-Agüero, Sara, Nandakumar, Anjali, Gupta, Namita T., Zhang, Wen, Atwal, Gurinder S., Murphy, Andrew J., Sleeman, Matthew A., Haxhinasto, Sokol
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7343867/
https://www.ncbi.nlm.nih.gov/pubmed/32641748
http://dx.doi.org/10.1038/s42003-020-1083-1

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