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Successful outcome of mucormycosis in a child with acute lymphoblastic leukemia

Invasive fungal infections may cause morbidity and mortality in pediatric patients with hematologic and oncologic malignancies treated with intensive protocols. We present a case of mucormycosis in an 8-year-old boy with acute lymphoblastic leukemia. In our patient, the suspicion for an oculoorbital...

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Autores principales: Kebudi, Rejin, Kızılocak, Hande, Hafız, Günter, Erturan, Zayre
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Kare Publishing 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7344120/
https://www.ncbi.nlm.nih.gov/pubmed/32684769
http://dx.doi.org/10.14744/TurkPediatriArs.2019.12129
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author Kebudi, Rejin
Kızılocak, Hande
Hafız, Günter
Erturan, Zayre
author_facet Kebudi, Rejin
Kızılocak, Hande
Hafız, Günter
Erturan, Zayre
author_sort Kebudi, Rejin
collection PubMed
description Invasive fungal infections may cause morbidity and mortality in pediatric patients with hematologic and oncologic malignancies treated with intensive protocols. We present a case of mucormycosis in an 8-year-old boy with acute lymphoblastic leukemia. In our patient, the suspicion for an oculoorbital and paranasal infection only due to mild pain in the orbital area without any abnormal pathologic findings in the ophthalmologic and otolaryngologic examination, led us to an early diagnosis. Despite the use of antifungal therapy, the lesion persisted and fever subsided after surgical drainage of the periorbital abscess. Antifungal treatment continued during chemotherapy. He has been in remission for four years. Mucormycosis should be in the differential diagnosis in infections in children with cancer, especially leukemia, according to clinical and radiologic findings. A high degree of suspicion and prompt systemic empirical antifungal therapy, as well as surgical debridement, are crucial for the survival of patients. Beside antifungals, early surgery plays an important role in patients with mucormycosis.
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spelling pubmed-73441202020-07-17 Successful outcome of mucormycosis in a child with acute lymphoblastic leukemia Kebudi, Rejin Kızılocak, Hande Hafız, Günter Erturan, Zayre Turk Pediatri Ars Case Report / Olgu Sunumu Invasive fungal infections may cause morbidity and mortality in pediatric patients with hematologic and oncologic malignancies treated with intensive protocols. We present a case of mucormycosis in an 8-year-old boy with acute lymphoblastic leukemia. In our patient, the suspicion for an oculoorbital and paranasal infection only due to mild pain in the orbital area without any abnormal pathologic findings in the ophthalmologic and otolaryngologic examination, led us to an early diagnosis. Despite the use of antifungal therapy, the lesion persisted and fever subsided after surgical drainage of the periorbital abscess. Antifungal treatment continued during chemotherapy. He has been in remission for four years. Mucormycosis should be in the differential diagnosis in infections in children with cancer, especially leukemia, according to clinical and radiologic findings. A high degree of suspicion and prompt systemic empirical antifungal therapy, as well as surgical debridement, are crucial for the survival of patients. Beside antifungals, early surgery plays an important role in patients with mucormycosis. Kare Publishing 2020-06-19 /pmc/articles/PMC7344120/ /pubmed/32684769 http://dx.doi.org/10.14744/TurkPediatriArs.2019.12129 Text en Copyright: © 2020 Turkish Archives of Pediatrics http://creativecommons.org/licenses/by-nc-sa/4.0 This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License
spellingShingle Case Report / Olgu Sunumu
Kebudi, Rejin
Kızılocak, Hande
Hafız, Günter
Erturan, Zayre
Successful outcome of mucormycosis in a child with acute lymphoblastic leukemia
title Successful outcome of mucormycosis in a child with acute lymphoblastic leukemia
title_full Successful outcome of mucormycosis in a child with acute lymphoblastic leukemia
title_fullStr Successful outcome of mucormycosis in a child with acute lymphoblastic leukemia
title_full_unstemmed Successful outcome of mucormycosis in a child with acute lymphoblastic leukemia
title_short Successful outcome of mucormycosis in a child with acute lymphoblastic leukemia
title_sort successful outcome of mucormycosis in a child with acute lymphoblastic leukemia
topic Case Report / Olgu Sunumu
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7344120/
https://www.ncbi.nlm.nih.gov/pubmed/32684769
http://dx.doi.org/10.14744/TurkPediatriArs.2019.12129
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