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Increased Dynamic Amplitude of Low Frequency Fluctuation in Primary Insomnia
The physiological mechanism underlying primary insomnia (PI) is poorly understood. Resting-state functional magnetic resonance imaging (fMRI) has emerged as a powerful tool to explore PI. However, previous studies ignore the dynamics of the brain activity. In the current study, we aimed to explore a...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7344192/ https://www.ncbi.nlm.nih.gov/pubmed/32714271 http://dx.doi.org/10.3389/fneur.2020.00609 |
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author | Meng, Xianyun Zheng, Jianjun Liu, Yingpeng Yin, Yi Hua, Kelei Fu, Shishun Wu, Yunfan Jiang, Guihua |
author_facet | Meng, Xianyun Zheng, Jianjun Liu, Yingpeng Yin, Yi Hua, Kelei Fu, Shishun Wu, Yunfan Jiang, Guihua |
author_sort | Meng, Xianyun |
collection | PubMed |
description | The physiological mechanism underlying primary insomnia (PI) is poorly understood. Resting-state functional magnetic resonance imaging (fMRI) has emerged as a powerful tool to explore PI. However, previous studies ignore the dynamics of the brain activity. In the current study, we aimed to explore altered dynamic intrinsic brain activity in PI. Fifty-nine patients with PI and 47 matched healthy controls (HCs) were recruited and underwent resting-state fMRI. The variance of dynamic amplitude of low frequency fluctuation (dALFF) maps across time was calculated to measure the temporal variability of intrinsic brain activity and then compared between patients with PI and HCs. As a result, patients with PI presented increased variance of dALFF in the bilateral hippocampus extending to the parahippocampus, the right putamen and the right anterior insula cortex. In addition, the variance of dALFF in the right putamen was positively correlated with Self-rating Anxiety Scale (SAS) score in PI. Our results revealed increased instability of intrinsic activity in PI. |
format | Online Article Text |
id | pubmed-7344192 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-73441922020-07-25 Increased Dynamic Amplitude of Low Frequency Fluctuation in Primary Insomnia Meng, Xianyun Zheng, Jianjun Liu, Yingpeng Yin, Yi Hua, Kelei Fu, Shishun Wu, Yunfan Jiang, Guihua Front Neurol Neurology The physiological mechanism underlying primary insomnia (PI) is poorly understood. Resting-state functional magnetic resonance imaging (fMRI) has emerged as a powerful tool to explore PI. However, previous studies ignore the dynamics of the brain activity. In the current study, we aimed to explore altered dynamic intrinsic brain activity in PI. Fifty-nine patients with PI and 47 matched healthy controls (HCs) were recruited and underwent resting-state fMRI. The variance of dynamic amplitude of low frequency fluctuation (dALFF) maps across time was calculated to measure the temporal variability of intrinsic brain activity and then compared between patients with PI and HCs. As a result, patients with PI presented increased variance of dALFF in the bilateral hippocampus extending to the parahippocampus, the right putamen and the right anterior insula cortex. In addition, the variance of dALFF in the right putamen was positively correlated with Self-rating Anxiety Scale (SAS) score in PI. Our results revealed increased instability of intrinsic activity in PI. Frontiers Media S.A. 2020-06-30 /pmc/articles/PMC7344192/ /pubmed/32714271 http://dx.doi.org/10.3389/fneur.2020.00609 Text en Copyright © 2020 Meng, Zheng, Liu, Yin, Hua, Fu, Wu and Jiang. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Neurology Meng, Xianyun Zheng, Jianjun Liu, Yingpeng Yin, Yi Hua, Kelei Fu, Shishun Wu, Yunfan Jiang, Guihua Increased Dynamic Amplitude of Low Frequency Fluctuation in Primary Insomnia |
title | Increased Dynamic Amplitude of Low Frequency Fluctuation in Primary Insomnia |
title_full | Increased Dynamic Amplitude of Low Frequency Fluctuation in Primary Insomnia |
title_fullStr | Increased Dynamic Amplitude of Low Frequency Fluctuation in Primary Insomnia |
title_full_unstemmed | Increased Dynamic Amplitude of Low Frequency Fluctuation in Primary Insomnia |
title_short | Increased Dynamic Amplitude of Low Frequency Fluctuation in Primary Insomnia |
title_sort | increased dynamic amplitude of low frequency fluctuation in primary insomnia |
topic | Neurology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7344192/ https://www.ncbi.nlm.nih.gov/pubmed/32714271 http://dx.doi.org/10.3389/fneur.2020.00609 |
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