Cargando…

Increased Dynamic Amplitude of Low Frequency Fluctuation in Primary Insomnia

The physiological mechanism underlying primary insomnia (PI) is poorly understood. Resting-state functional magnetic resonance imaging (fMRI) has emerged as a powerful tool to explore PI. However, previous studies ignore the dynamics of the brain activity. In the current study, we aimed to explore a...

Descripción completa

Detalles Bibliográficos
Autores principales: Meng, Xianyun, Zheng, Jianjun, Liu, Yingpeng, Yin, Yi, Hua, Kelei, Fu, Shishun, Wu, Yunfan, Jiang, Guihua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7344192/
https://www.ncbi.nlm.nih.gov/pubmed/32714271
http://dx.doi.org/10.3389/fneur.2020.00609
_version_ 1783555893555625984
author Meng, Xianyun
Zheng, Jianjun
Liu, Yingpeng
Yin, Yi
Hua, Kelei
Fu, Shishun
Wu, Yunfan
Jiang, Guihua
author_facet Meng, Xianyun
Zheng, Jianjun
Liu, Yingpeng
Yin, Yi
Hua, Kelei
Fu, Shishun
Wu, Yunfan
Jiang, Guihua
author_sort Meng, Xianyun
collection PubMed
description The physiological mechanism underlying primary insomnia (PI) is poorly understood. Resting-state functional magnetic resonance imaging (fMRI) has emerged as a powerful tool to explore PI. However, previous studies ignore the dynamics of the brain activity. In the current study, we aimed to explore altered dynamic intrinsic brain activity in PI. Fifty-nine patients with PI and 47 matched healthy controls (HCs) were recruited and underwent resting-state fMRI. The variance of dynamic amplitude of low frequency fluctuation (dALFF) maps across time was calculated to measure the temporal variability of intrinsic brain activity and then compared between patients with PI and HCs. As a result, patients with PI presented increased variance of dALFF in the bilateral hippocampus extending to the parahippocampus, the right putamen and the right anterior insula cortex. In addition, the variance of dALFF in the right putamen was positively correlated with Self-rating Anxiety Scale (SAS) score in PI. Our results revealed increased instability of intrinsic activity in PI.
format Online
Article
Text
id pubmed-7344192
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-73441922020-07-25 Increased Dynamic Amplitude of Low Frequency Fluctuation in Primary Insomnia Meng, Xianyun Zheng, Jianjun Liu, Yingpeng Yin, Yi Hua, Kelei Fu, Shishun Wu, Yunfan Jiang, Guihua Front Neurol Neurology The physiological mechanism underlying primary insomnia (PI) is poorly understood. Resting-state functional magnetic resonance imaging (fMRI) has emerged as a powerful tool to explore PI. However, previous studies ignore the dynamics of the brain activity. In the current study, we aimed to explore altered dynamic intrinsic brain activity in PI. Fifty-nine patients with PI and 47 matched healthy controls (HCs) were recruited and underwent resting-state fMRI. The variance of dynamic amplitude of low frequency fluctuation (dALFF) maps across time was calculated to measure the temporal variability of intrinsic brain activity and then compared between patients with PI and HCs. As a result, patients with PI presented increased variance of dALFF in the bilateral hippocampus extending to the parahippocampus, the right putamen and the right anterior insula cortex. In addition, the variance of dALFF in the right putamen was positively correlated with Self-rating Anxiety Scale (SAS) score in PI. Our results revealed increased instability of intrinsic activity in PI. Frontiers Media S.A. 2020-06-30 /pmc/articles/PMC7344192/ /pubmed/32714271 http://dx.doi.org/10.3389/fneur.2020.00609 Text en Copyright © 2020 Meng, Zheng, Liu, Yin, Hua, Fu, Wu and Jiang. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neurology
Meng, Xianyun
Zheng, Jianjun
Liu, Yingpeng
Yin, Yi
Hua, Kelei
Fu, Shishun
Wu, Yunfan
Jiang, Guihua
Increased Dynamic Amplitude of Low Frequency Fluctuation in Primary Insomnia
title Increased Dynamic Amplitude of Low Frequency Fluctuation in Primary Insomnia
title_full Increased Dynamic Amplitude of Low Frequency Fluctuation in Primary Insomnia
title_fullStr Increased Dynamic Amplitude of Low Frequency Fluctuation in Primary Insomnia
title_full_unstemmed Increased Dynamic Amplitude of Low Frequency Fluctuation in Primary Insomnia
title_short Increased Dynamic Amplitude of Low Frequency Fluctuation in Primary Insomnia
title_sort increased dynamic amplitude of low frequency fluctuation in primary insomnia
topic Neurology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7344192/
https://www.ncbi.nlm.nih.gov/pubmed/32714271
http://dx.doi.org/10.3389/fneur.2020.00609
work_keys_str_mv AT mengxianyun increaseddynamicamplitudeoflowfrequencyfluctuationinprimaryinsomnia
AT zhengjianjun increaseddynamicamplitudeoflowfrequencyfluctuationinprimaryinsomnia
AT liuyingpeng increaseddynamicamplitudeoflowfrequencyfluctuationinprimaryinsomnia
AT yinyi increaseddynamicamplitudeoflowfrequencyfluctuationinprimaryinsomnia
AT huakelei increaseddynamicamplitudeoflowfrequencyfluctuationinprimaryinsomnia
AT fushishun increaseddynamicamplitudeoflowfrequencyfluctuationinprimaryinsomnia
AT wuyunfan increaseddynamicamplitudeoflowfrequencyfluctuationinprimaryinsomnia
AT jiangguihua increaseddynamicamplitudeoflowfrequencyfluctuationinprimaryinsomnia