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Death-associated Protein Kinase 1 Phosphorylates α-Synuclein at Ser129 and Exacerbates Rotenone-induced Toxic Aggregation of α-Synuclein in Dopaminergic SH-SY5Y Cells

The formation of Lewy bodies (LBs), intracellular filamentous inclusions, is one of the hallmarks of Parkinson's disease (PD). α-Synuclein is the main component of LBs and its abnormal accumulation contributes to the pathogenesis of PD. Direct phosphorylation of α-synuclein at multiple Ser/Tyr...

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Detalles Bibliográficos
Autores principales:	Shin, Woo Hyun, Chung, Kwang Chul
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Korean Society for Brain and Neural Sciences 2020
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7344377/ https://www.ncbi.nlm.nih.gov/pubmed/32624505 http://dx.doi.org/10.5607/en20014

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