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Sexual Function in Levothyroxine-Treated Hypothyroid Women and Women without Hypothyroidism: A Case-Control

Background: Levothyroxine is the most common treatment to normalize thyroid hormones levels and to reduce primary hypothyroidism symptoms. Aim: To assess sexual function in women with levothyroxine-treated hypothyroidism and women without hypothyroidism. Methods: A case-control study was performed w...

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Autores principales: Romero-Gómez, Benjamín, Guerrero-Alonso, Paula, Carmona-Torres, Juan Manuel, Laredo-Aguilera, José Alberto, Pozuelo-Carrascosa, Diana Patricia, Cobo-Cuenca, Ana Isabel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7344388/
https://www.ncbi.nlm.nih.gov/pubmed/32560383
http://dx.doi.org/10.3390/ijerph17124325
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author Romero-Gómez, Benjamín
Guerrero-Alonso, Paula
Carmona-Torres, Juan Manuel
Laredo-Aguilera, José Alberto
Pozuelo-Carrascosa, Diana Patricia
Cobo-Cuenca, Ana Isabel
author_facet Romero-Gómez, Benjamín
Guerrero-Alonso, Paula
Carmona-Torres, Juan Manuel
Laredo-Aguilera, José Alberto
Pozuelo-Carrascosa, Diana Patricia
Cobo-Cuenca, Ana Isabel
author_sort Romero-Gómez, Benjamín
collection PubMed
description Background: Levothyroxine is the most common treatment to normalize thyroid hormones levels and to reduce primary hypothyroidism symptoms. Aim: To assess sexual function in women with levothyroxine-treated hypothyroidism and women without hypothyroidism. Methods: A case-control study was performed with 152 women with levothyroxine-treated hypothyroidism and 238 women without hypothyroidism. An online survey was used to collect socio-demographic data and the answers to the Women Sexual Function (WSF) questionnaire. Results: Women with levothyroxine-treated hypothyroidism showed a higher prevalence of sexual dysfunction than women in the control group (31.60% vs. 16.40%), furthermore the presence of hypothyroidism increased the risk of sexual dysfunction (p = 0.002, OR: 2.29 (1.36−3.88)). The most affected domains were ‘desire’ (p < 0.001), ‘arousal’ (p = 0.003) and ‘penetration pain’ (p = 0.020). In hypothyroid women, age increased the risk of sexual dysfunctions (p = 0.009, OR: 1.07 (1.01−1.12)), however when age was adjusted (ANCOVA) the sexual dysfunction remained in women with hypothyroidism in all domains. Conclusions: Hypothyroidism is associated with an increase in the prevalence of sexual dysfunction even if treated with levothyroxine and thyroid-stimulating hormone (TSH) levels are normalized. Relevance to clinical practice: Sexual function in hypothyroid women should be assessed before and after starting the treatment.
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spelling pubmed-73443882020-07-14 Sexual Function in Levothyroxine-Treated Hypothyroid Women and Women without Hypothyroidism: A Case-Control Romero-Gómez, Benjamín Guerrero-Alonso, Paula Carmona-Torres, Juan Manuel Laredo-Aguilera, José Alberto Pozuelo-Carrascosa, Diana Patricia Cobo-Cuenca, Ana Isabel Int J Environ Res Public Health Article Background: Levothyroxine is the most common treatment to normalize thyroid hormones levels and to reduce primary hypothyroidism symptoms. Aim: To assess sexual function in women with levothyroxine-treated hypothyroidism and women without hypothyroidism. Methods: A case-control study was performed with 152 women with levothyroxine-treated hypothyroidism and 238 women without hypothyroidism. An online survey was used to collect socio-demographic data and the answers to the Women Sexual Function (WSF) questionnaire. Results: Women with levothyroxine-treated hypothyroidism showed a higher prevalence of sexual dysfunction than women in the control group (31.60% vs. 16.40%), furthermore the presence of hypothyroidism increased the risk of sexual dysfunction (p = 0.002, OR: 2.29 (1.36−3.88)). The most affected domains were ‘desire’ (p < 0.001), ‘arousal’ (p = 0.003) and ‘penetration pain’ (p = 0.020). In hypothyroid women, age increased the risk of sexual dysfunctions (p = 0.009, OR: 1.07 (1.01−1.12)), however when age was adjusted (ANCOVA) the sexual dysfunction remained in women with hypothyroidism in all domains. Conclusions: Hypothyroidism is associated with an increase in the prevalence of sexual dysfunction even if treated with levothyroxine and thyroid-stimulating hormone (TSH) levels are normalized. Relevance to clinical practice: Sexual function in hypothyroid women should be assessed before and after starting the treatment. MDPI 2020-06-17 2020-06 /pmc/articles/PMC7344388/ /pubmed/32560383 http://dx.doi.org/10.3390/ijerph17124325 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Romero-Gómez, Benjamín
Guerrero-Alonso, Paula
Carmona-Torres, Juan Manuel
Laredo-Aguilera, José Alberto
Pozuelo-Carrascosa, Diana Patricia
Cobo-Cuenca, Ana Isabel
Sexual Function in Levothyroxine-Treated Hypothyroid Women and Women without Hypothyroidism: A Case-Control
title Sexual Function in Levothyroxine-Treated Hypothyroid Women and Women without Hypothyroidism: A Case-Control
title_full Sexual Function in Levothyroxine-Treated Hypothyroid Women and Women without Hypothyroidism: A Case-Control
title_fullStr Sexual Function in Levothyroxine-Treated Hypothyroid Women and Women without Hypothyroidism: A Case-Control
title_full_unstemmed Sexual Function in Levothyroxine-Treated Hypothyroid Women and Women without Hypothyroidism: A Case-Control
title_short Sexual Function in Levothyroxine-Treated Hypothyroid Women and Women without Hypothyroidism: A Case-Control
title_sort sexual function in levothyroxine-treated hypothyroid women and women without hypothyroidism: a case-control
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7344388/
https://www.ncbi.nlm.nih.gov/pubmed/32560383
http://dx.doi.org/10.3390/ijerph17124325
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