Leptogorgins A–C, Humulane Sesquiterpenoids from the Vietnamese Gorgonian Leptogorgia sp.

Leptogorgins A–C (1–3), new humulane sesquiterpenoids, and leptogorgoid A (4), a new dihydroxyketosteroid, were isolated from the gorgonian Leptogorgia sp. collected from the South China Sea. The structures were established using MS and NMR data. The absolute configuration of 1 was confirmed by a mo...

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Autores principales: Kapustina, Irina I., Makarieva, Tatyana N., Guzii, Alla G., Kalinovsky, Anatoly I., Popov, Roman S., Dyshlovoy, Sergey A., Grebnev, Boris B., von Amsberg, Gunhild, Stonik, Valentin A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
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Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7344390/
https://www.ncbi.nlm.nih.gov/pubmed/32545757
http://dx.doi.org/10.3390/md18060310
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author Kapustina, Irina I.
Makarieva, Tatyana N.
Guzii, Alla G.
Kalinovsky, Anatoly I.
Popov, Roman S.
Dyshlovoy, Sergey A.
Grebnev, Boris B.
von Amsberg, Gunhild
Stonik, Valentin A.
author_facet Kapustina, Irina I.
Makarieva, Tatyana N.
Guzii, Alla G.
Kalinovsky, Anatoly I.
Popov, Roman S.
Dyshlovoy, Sergey A.
Grebnev, Boris B.
von Amsberg, Gunhild
Stonik, Valentin A.
author_sort Kapustina, Irina I.
collection PubMed
description Leptogorgins A–C (1–3), new humulane sesquiterpenoids, and leptogorgoid A (4), a new dihydroxyketosteroid, were isolated from the gorgonian Leptogorgia sp. collected from the South China Sea. The structures were established using MS and NMR data. The absolute configuration of 1 was confirmed by a modification of Mosher’s method. Configurations of double bonds followed from NMR data, including NOE correlations. This is the first report of humulane-type sesquiterpenoids from marine invertebrates. Sesquiterpenoids leptogorgins A (1) and B (2) exhibited a moderate cytotoxicity and some selectivity against human drug-resistant prostate cancer cells 22Rv1.
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spelling pubmed-73443902020-07-14 Leptogorgins A–C, Humulane Sesquiterpenoids from the Vietnamese Gorgonian Leptogorgia sp. Kapustina, Irina I. Makarieva, Tatyana N. Guzii, Alla G. Kalinovsky, Anatoly I. Popov, Roman S. Dyshlovoy, Sergey A. Grebnev, Boris B. von Amsberg, Gunhild Stonik, Valentin A. Mar Drugs Article Leptogorgins A–C (1–3), new humulane sesquiterpenoids, and leptogorgoid A (4), a new dihydroxyketosteroid, were isolated from the gorgonian Leptogorgia sp. collected from the South China Sea. The structures were established using MS and NMR data. The absolute configuration of 1 was confirmed by a modification of Mosher’s method. Configurations of double bonds followed from NMR data, including NOE correlations. This is the first report of humulane-type sesquiterpenoids from marine invertebrates. Sesquiterpenoids leptogorgins A (1) and B (2) exhibited a moderate cytotoxicity and some selectivity against human drug-resistant prostate cancer cells 22Rv1. MDPI 2020-06-13 /pmc/articles/PMC7344390/ /pubmed/32545757 http://dx.doi.org/10.3390/md18060310 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Kapustina, Irina I.
Makarieva, Tatyana N.
Guzii, Alla G.
Kalinovsky, Anatoly I.
Popov, Roman S.
Dyshlovoy, Sergey A.
Grebnev, Boris B.
von Amsberg, Gunhild
Stonik, Valentin A.
Leptogorgins A–C, Humulane Sesquiterpenoids from the Vietnamese Gorgonian Leptogorgia sp.
title Leptogorgins A–C, Humulane Sesquiterpenoids from the Vietnamese Gorgonian Leptogorgia sp.
title_full Leptogorgins A–C, Humulane Sesquiterpenoids from the Vietnamese Gorgonian Leptogorgia sp.
title_fullStr Leptogorgins A–C, Humulane Sesquiterpenoids from the Vietnamese Gorgonian Leptogorgia sp.
title_full_unstemmed Leptogorgins A–C, Humulane Sesquiterpenoids from the Vietnamese Gorgonian Leptogorgia sp.
title_short Leptogorgins A–C, Humulane Sesquiterpenoids from the Vietnamese Gorgonian Leptogorgia sp.
title_sort leptogorgins a–c, humulane sesquiterpenoids from the vietnamese gorgonian leptogorgia sp.
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7344390/
https://www.ncbi.nlm.nih.gov/pubmed/32545757
http://dx.doi.org/10.3390/md18060310
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