Cargando…

Antibiotic-Induced Changes in Microbiome-Related Metabolites and Bile Acids in Rat Plasma

Various environmental factors can alter the gut microbiome’s composition and functionality, and modulate host health. In this study, the effects of oral and parenteral administration of two poorly bioavailable antibiotics (i.e., vancomycin and streptomycin) on male Wistar Crl/Wi(Han) rats for 28 day...

Descripción completa

Detalles Bibliográficos
Autores principales:	de Bruijn, Véronique, Behr, Christina, Sperber, Saskia, Walk, Tilmann, Ternes, Philipp, Slopianka, Markus, Haake, Volker, Beekmann, Karsten, van Ravenzwaay, Bennard
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7344402/ https://www.ncbi.nlm.nih.gov/pubmed/32545183 http://dx.doi.org/10.3390/metabo10060242

Ejemplares similares

Gut Microbiota as Well as Metabolomes of Wistar Rats Recover within Two Weeks after Doripenem Antibiotic Treatment
por: Murali, Aishwarya, et al.
Publicado: (2023)

In vitro models to detect in vivo bile acid changes induced by antibiotics
por: Zhang, Nina, et al.
Publicado: (2022)

Application of high throughput in vitro metabolomics for hepatotoxicity mode of action characterization and mechanistic-anchored point of departure derivation: a case study with nitrofurantoin
por: Ramirez-Hincapie, Sabina, et al.
Publicado: (2023)

Gut microbiome and plasma metabolome changes in rats after oral gavage of nanoparticles: sensitive indicators of possible adverse health effects
por: Landsiedel, Robert, et al.
Publicado: (2022)

A high-throughput metabolomics in vitro platform for the characterization of hepatotoxicity
por: Ramirez-Hincapie, Sabina, et al.
Publicado: (2023)

Prediction of liver toxicity and mode of action using metabolomics in vitro in HepG2 cells
por: Ramirez, Tzutzuy, et al.
Publicado: (2017)

Development of a Generic Physiologically Based Kinetic Model to Predict In Vivo Uterotrophic Responses Induced by Estrogenic Chemicals in Rats Based on In Vitro Bioassays
por: Zhang, Mengying, et al.
Publicado: (2020)

Predictive Performance of Next Generation Physiologically Based Kinetic (PBK) Model Predictions in Rats Based on In Vitro and In Silico Input Data
por: Punt, Ans, et al.
Publicado: (2021)

Body and organ weight data in 28-day toxicological studies in two mouse strains
por: Marxfeld, Heike Antje, et al.
Publicado: (2019)

Use of Physiologically Based Kinetic Modeling-Facilitated Reverse Dosimetry to Predict In Vivo Acute Toxicity of Tetrodotoxin in Rodents
por: Noorlander, Annelies, et al.
Publicado: (2022)

Novel testing strategy for prediction of rat biliary excretion of intravenously administered estradiol-17β glucuronide
por: Noorlander, Annelies, et al.
Publicado: (2020)

Effects of SiO(2), ZrO(2), and BaSO(4) nanomaterials with or without surface functionalization upon 28-day oral exposure to rats
por: Buesen, Roland, et al.
Publicado: (2014)

Investigations on the dose–response relationship of combined exposure to low doses of three anti-androgens in Wistar rats
por: Schneider, Steffen, et al.
Publicado: (2017)

Antibiotic perturbation of the murine gut microbiome introduces inter-individual susceptibility to arsenic
por: Roggenbeck, Barbara A., et al.
Publicado: (2021)

Towards a generic physiologically based kinetic model to predict in vivo uterotrophic responses in rats by reverse dosimetry of in vitro estrogenicity data
por: Zhang, Mengying, et al.
Publicado: (2017)

Bile Microbiome in Patients with Recurrent Common Bile Duct Stones and Correlation with the Duodenal Microbiome
por: Lee, Jungnam, et al.
Publicado: (2022)

Application of short-term inhalation studies to assess the inhalation toxicity of nanomaterials
por: Landsiedel, Robert, et al.
Publicado: (2014)

Comparative inhalation toxicity of multi-wall carbon nanotubes, graphene, graphite nanoplatelets and low surface carbon black
por: Ma-Hock, Lan, et al.
Publicado: (2013)

Use cases, best practice and reporting standards for metabolomics in regulatory toxicology
por: Viant, Mark R., et al.
Publicado: (2019)

Extended evaluation on the ES-D3 cell differentiation assay combined with the BeWo transport model, to predict relative developmental toxicity of triazole compounds
por: Li, Hequn, et al.
Publicado: (2015)

Gut Microbiome-Linked Metabolites in the Pathobiology of Major Depression With or Without Anxiety—A Role for Bile Acids
por: MahmoudianDehkordi, Siamak, et al.
Publicado: (2022)

Alterations of the Bile Microbiome in Recurrent Common Bile Duct Stone
por: Ye, Cheng, et al.
Publicado: (2020)

The Role of the Bile Microbiome in Common Bile Duct Stone Development
por: Lee, Jungnam, et al.
Publicado: (2023)

4444 The effect of early life antibiotics on gut microbiome and fecal bile acid concentrations in children
por: Benitez, Alain Jesus, et al.
Publicado: (2020)

Time course of lung retention and toxicity of inhaled particles: short-term exposure to nano-Ceria
por: Keller, Jana, et al.
Publicado: (2014)

The pathophysiology of bile acid diarrhoea: differences in the colonic microbiome, metabolome and bile acids
por: Sagar, Nidhi M., et al.
Publicado: (2020)

Inter- and Intraindividual Differences in the Capacity of the Human Intestinal Microbiome in Fecal Slurries to Metabolize Fructoselysine and Carboxymethyllysine
por: van Dongen, Katja C. W., et al.
Publicado: (2022)

Bile metabolites as diagnostic biomarkers for perihilar cholangiocarcinoma
por: Zhang, DengYong, et al.
Publicado: (2023)

Population pharmacokinetic model to generate mechanistic insights in bile acid homeostasis and drug-induced cholestasis
por: de Bruijn, Véronique M. P., et al.
Publicado: (2022)

Bile Acids: Major Regulator of the Gut Microbiome
por: An, Chihyeok, et al.
Publicado: (2022)

Green Toxicology: a strategy for sustainable chemical and material development
por: Crawford, Sarah E., et al.
Publicado: (2017)

Bile salt hydrolases: Gatekeepers of bile acid metabolism and host-microbiome crosstalk in the gastrointestinal tract
por: Foley, Matthew H., et al.
Publicado: (2019)

Rethinking the bile acid/gut microbiome axis in cancer
por: Phelan, John P., et al.
Publicado: (2017)

Variation in Bile Microbiome by the Etiology of Cholestatic Liver Disease
por: Tyc, Olaf, et al.
Publicado: (2020)

Physiological Role of Bile Acids Modified by the Gut Microbiome
por: Kiriyama, Yoshimitsu, et al.
Publicado: (2021)

Bile Acid–Microbiome Interaction Promotes Gastric Carcinogenesis
por: Wang, Shouli, et al.
Publicado: (2022)

Comparative short-term inhalation toxicity of five organic diketopyrrolopyrrole pigments and two inorganic iron-oxide-based pigments
por: Hofmann, Thomas, et al.
Publicado: (2016)

Prediction of Clinically Relevant Safety Signals of Nephrotoxicity through Plasma Metabolite Profiling
por: Mattes, W. B., et al.
Publicado: (2013)

The Production of Antibiotics Must Be Reoriented: Repositioning Old Narrow-Spectrum Antibiotics, Developing New Microbiome-Sparing Antibiotics
por: Diamantis, Sylvain, et al.
Publicado: (2022)

Tubular bile duct structure mimicking bile duct morphogenesis for prospective in vitro liver metabolite recovery
por: Rizki-Safitri, Astia, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_ng1f4jsv0davuoricq9trk8fec