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Lymphoid Tissue in Teleost Gills: Variations on a Theme

In bony fish, the gill filaments are essential for gas exchanges, but also are vulnerable to infection by water-borne microorganisms. Omnipresent across fish, gill-associated lymphoid tissues (GIALT) regulate interactions with local microbiota and halt infection by pathogens. A special GIALT structu...

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Autores principales: Rességuier, Julien, Dalum, Alf S., Du Pasquier, Louis, Zhang, Yaqing, Koppang, Erling Olaf, Boudinot, Pierre, Wiegertjes, Geert F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7344468/
https://www.ncbi.nlm.nih.gov/pubmed/32549335
http://dx.doi.org/10.3390/biology9060127
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author Rességuier, Julien
Dalum, Alf S.
Du Pasquier, Louis
Zhang, Yaqing
Koppang, Erling Olaf
Boudinot, Pierre
Wiegertjes, Geert F.
author_facet Rességuier, Julien
Dalum, Alf S.
Du Pasquier, Louis
Zhang, Yaqing
Koppang, Erling Olaf
Boudinot, Pierre
Wiegertjes, Geert F.
author_sort Rességuier, Julien
collection PubMed
description In bony fish, the gill filaments are essential for gas exchanges, but also are vulnerable to infection by water-borne microorganisms. Omnipresent across fish, gill-associated lymphoid tissues (GIALT) regulate interactions with local microbiota and halt infection by pathogens. A special GIALT structure has recently been found in Salmonids, the interbranchial lymphoid tissue (ILT). However, the structural variation of GIALT across bony fish remains largely unknown. Here, we show how this critical zone of interaction evolved across fishes. By labeling a conserved T-cell epitope on tissue sections, we find that several basal groups of teleosts possess typical ILT, while modern teleosts have lymphoepithelium of different shape and size at the base of primary gill filaments. Within Cypriniformes, neither body size variation between two related species, zebrafish and common carp, nor morphotype variation, did have a drastic effect on the structure of ILT. Thereby this study is the first to describe the presence of ILT in zebrafish. The ILT variability across fish orders seems to represent different evolutionary solutions to balancing trade-offs between multiple adaptations of jaws and pharyngeal region, and immune responses. Our data point to a wide structural variation in gill immunity between basal groups and modern teleosts.
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spelling pubmed-73444682020-07-14 Lymphoid Tissue in Teleost Gills: Variations on a Theme Rességuier, Julien Dalum, Alf S. Du Pasquier, Louis Zhang, Yaqing Koppang, Erling Olaf Boudinot, Pierre Wiegertjes, Geert F. Biology (Basel) Article In bony fish, the gill filaments are essential for gas exchanges, but also are vulnerable to infection by water-borne microorganisms. Omnipresent across fish, gill-associated lymphoid tissues (GIALT) regulate interactions with local microbiota and halt infection by pathogens. A special GIALT structure has recently been found in Salmonids, the interbranchial lymphoid tissue (ILT). However, the structural variation of GIALT across bony fish remains largely unknown. Here, we show how this critical zone of interaction evolved across fishes. By labeling a conserved T-cell epitope on tissue sections, we find that several basal groups of teleosts possess typical ILT, while modern teleosts have lymphoepithelium of different shape and size at the base of primary gill filaments. Within Cypriniformes, neither body size variation between two related species, zebrafish and common carp, nor morphotype variation, did have a drastic effect on the structure of ILT. Thereby this study is the first to describe the presence of ILT in zebrafish. The ILT variability across fish orders seems to represent different evolutionary solutions to balancing trade-offs between multiple adaptations of jaws and pharyngeal region, and immune responses. Our data point to a wide structural variation in gill immunity between basal groups and modern teleosts. MDPI 2020-06-15 /pmc/articles/PMC7344468/ /pubmed/32549335 http://dx.doi.org/10.3390/biology9060127 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Rességuier, Julien
Dalum, Alf S.
Du Pasquier, Louis
Zhang, Yaqing
Koppang, Erling Olaf
Boudinot, Pierre
Wiegertjes, Geert F.
Lymphoid Tissue in Teleost Gills: Variations on a Theme
title Lymphoid Tissue in Teleost Gills: Variations on a Theme
title_full Lymphoid Tissue in Teleost Gills: Variations on a Theme
title_fullStr Lymphoid Tissue in Teleost Gills: Variations on a Theme
title_full_unstemmed Lymphoid Tissue in Teleost Gills: Variations on a Theme
title_short Lymphoid Tissue in Teleost Gills: Variations on a Theme
title_sort lymphoid tissue in teleost gills: variations on a theme
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7344468/
https://www.ncbi.nlm.nih.gov/pubmed/32549335
http://dx.doi.org/10.3390/biology9060127
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