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First Evidence of the Presence of Anatoxin-A in Sea Figs Associated with Human Food Poisonings in France

From January 2011 to March 2018, 26 patients aged from 20 to 80 years old reported being sick in France after eating sea figs of the genus Microcosmus. The patients had symptoms evoking a cerebellar syndrome: blurred or double vision, ataxia and dizziness, asthenia, headache, muscle cramps, paresthe...

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Autores principales: Biré, Ronel, Bertin, Thomas, Dom, Inès, Hort, Vincent, Schmitt, Corinne, Diogène, Jorge, Lemée, Rodolphe, De Haro, Luc, Nicolas, Marina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7344475/
https://www.ncbi.nlm.nih.gov/pubmed/32485965
http://dx.doi.org/10.3390/md18060285
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author Biré, Ronel
Bertin, Thomas
Dom, Inès
Hort, Vincent
Schmitt, Corinne
Diogène, Jorge
Lemée, Rodolphe
De Haro, Luc
Nicolas, Marina
author_facet Biré, Ronel
Bertin, Thomas
Dom, Inès
Hort, Vincent
Schmitt, Corinne
Diogène, Jorge
Lemée, Rodolphe
De Haro, Luc
Nicolas, Marina
author_sort Biré, Ronel
collection PubMed
description From January 2011 to March 2018, 26 patients aged from 20 to 80 years old reported being sick in France after eating sea figs of the genus Microcosmus. The patients had symptoms evoking a cerebellar syndrome: blurred or double vision, ataxia and dizziness, asthenia, headache, muscle cramps, paresthesia and digestive disorders (nausea, vomiting and diarrhea). Three of the 18 food poisoning events recorded by the Poison Control Center in Marseille and involving four patients were further investigated as the meal leftovers were collected and analyzed. A previous study ruled out the presence of the regulated lipophilic marine toxins after high-resolution mass spectrometry, but further analyses were required to look for hydrophilic cyanotoxins. The sea fig leftovers from food poisoning case Numbers 1 (January 2011), 6 (December 2012) and 17 (March 2018) of this published case series were analyzed by hydrophilic interaction liquid chromatography coupled to low- and high-resolution mass spectrometry to investigate the presence of hydrophilic cyanotoxins. The sea fig samples showed anatoxin-a (ATX-a) concentrations ranging from 193.7 to 1240.2 µg/kg. The sea fig control sample analyzed was also contaminated with ATX-a but in a much smaller concentration (22.5 µg/kg). To the best of our knowledge, this is the first report of human food poisoning involving ATX-a as the possible causative toxin where the cyanotoxin could be unequivocally identified.
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spelling pubmed-73444752020-07-14 First Evidence of the Presence of Anatoxin-A in Sea Figs Associated with Human Food Poisonings in France Biré, Ronel Bertin, Thomas Dom, Inès Hort, Vincent Schmitt, Corinne Diogène, Jorge Lemée, Rodolphe De Haro, Luc Nicolas, Marina Mar Drugs Article From January 2011 to March 2018, 26 patients aged from 20 to 80 years old reported being sick in France after eating sea figs of the genus Microcosmus. The patients had symptoms evoking a cerebellar syndrome: blurred or double vision, ataxia and dizziness, asthenia, headache, muscle cramps, paresthesia and digestive disorders (nausea, vomiting and diarrhea). Three of the 18 food poisoning events recorded by the Poison Control Center in Marseille and involving four patients were further investigated as the meal leftovers were collected and analyzed. A previous study ruled out the presence of the regulated lipophilic marine toxins after high-resolution mass spectrometry, but further analyses were required to look for hydrophilic cyanotoxins. The sea fig leftovers from food poisoning case Numbers 1 (January 2011), 6 (December 2012) and 17 (March 2018) of this published case series were analyzed by hydrophilic interaction liquid chromatography coupled to low- and high-resolution mass spectrometry to investigate the presence of hydrophilic cyanotoxins. The sea fig samples showed anatoxin-a (ATX-a) concentrations ranging from 193.7 to 1240.2 µg/kg. The sea fig control sample analyzed was also contaminated with ATX-a but in a much smaller concentration (22.5 µg/kg). To the best of our knowledge, this is the first report of human food poisoning involving ATX-a as the possible causative toxin where the cyanotoxin could be unequivocally identified. MDPI 2020-05-29 /pmc/articles/PMC7344475/ /pubmed/32485965 http://dx.doi.org/10.3390/md18060285 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Biré, Ronel
Bertin, Thomas
Dom, Inès
Hort, Vincent
Schmitt, Corinne
Diogène, Jorge
Lemée, Rodolphe
De Haro, Luc
Nicolas, Marina
First Evidence of the Presence of Anatoxin-A in Sea Figs Associated with Human Food Poisonings in France
title First Evidence of the Presence of Anatoxin-A in Sea Figs Associated with Human Food Poisonings in France
title_full First Evidence of the Presence of Anatoxin-A in Sea Figs Associated with Human Food Poisonings in France
title_fullStr First Evidence of the Presence of Anatoxin-A in Sea Figs Associated with Human Food Poisonings in France
title_full_unstemmed First Evidence of the Presence of Anatoxin-A in Sea Figs Associated with Human Food Poisonings in France
title_short First Evidence of the Presence of Anatoxin-A in Sea Figs Associated with Human Food Poisonings in France
title_sort first evidence of the presence of anatoxin-a in sea figs associated with human food poisonings in france
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7344475/
https://www.ncbi.nlm.nih.gov/pubmed/32485965
http://dx.doi.org/10.3390/md18060285
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