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Phytochemical Compositions and Biological Activities of Essential Oils from the Leaves, Rhizomes and Whole Plant of Hornstedtia bella Škorničk
The rapid emergence of drug-resistant strains and novel viruses have motivated the search for new anti-infectious agents. In this study, the chemical compositions and cytotoxicity, as well as the antibacterial, antifungal, antitrichomonas, and antiviral activities of essential oils from the leaves,...
Autores principales: | , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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MDPI
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7344524/ https://www.ncbi.nlm.nih.gov/pubmed/32570731 http://dx.doi.org/10.3390/antibiotics9060334 |
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author | Donadu, Matthew Gavino Trong Le, Nhan Viet Ho, Duc Quoc Doan, Tuan Tuan Le, Anh Raal, Ain Usai, Marianna Marchetti, Mauro Sanna, Giuseppina Madeddu, Silvia Rappelli, Paola Diaz, Nicia Molicotti, Paola Carta, Antonio Piras, Sandra Usai, Donatella Thi Nguyen, Hoai Cappuccinelli, Piero Zanetti, Stefania |
author_facet | Donadu, Matthew Gavino Trong Le, Nhan Viet Ho, Duc Quoc Doan, Tuan Tuan Le, Anh Raal, Ain Usai, Marianna Marchetti, Mauro Sanna, Giuseppina Madeddu, Silvia Rappelli, Paola Diaz, Nicia Molicotti, Paola Carta, Antonio Piras, Sandra Usai, Donatella Thi Nguyen, Hoai Cappuccinelli, Piero Zanetti, Stefania |
author_sort | Donadu, Matthew Gavino |
collection | PubMed |
description | The rapid emergence of drug-resistant strains and novel viruses have motivated the search for new anti-infectious agents. In this study, the chemical compositions and cytotoxicity, as well as the antibacterial, antifungal, antitrichomonas, and antiviral activities of essential oils from the leaves, rhizomes, and whole plant of Hornstedtia bella were investigated. The GC/MS analysis showed that β-pinene, E-β-caryophyllene, and α-humulene were found at high concentrations in the essential oils. The essential oils exhibited (i) inhibition against Staphylococcus aureus, methicillin-resistant Staphylococcus aureus, Staphylococcus epidermidis with minimum inhibitory concentrations (MIC) and minimum lethal concentration (MLC) values from 1 to 4% (v/v); (ii) MIC and MLC values from 2 to 16% (v/v) in Candida tropicalis and Candida parapsilosis; (iii) MIC and MLC values from 4 to 16% in Enterococcus faecalis; and (iv) MIC and MLC values from 8 to greater than or equal to 16% (v/v) in the remaining strains, including Escherichia coli, Pseudomonas aeruginosa, Klebsiella pneumoniae, Candida albicans, and Candida glabrata. In antitrichomonas activity, the leaves and whole-plant oils of Hornstedtia bella possessed IC(50), IC(90), and MLC values of 0.008%, 0.016%, and 0.03% (v/v), respectively, whilst those of rhizomes oil had in turn, 0.004%, 0.008%, and 0.016% (v/v).Besides, the leaf oil showed a weak cytotoxicity against Vero 76 and MRC-5; meanwhile, rhizomes and whole-plant oils did not exert any toxic effects on cell monolayers. Finally, these oils were not active against EV-A71. |
format | Online Article Text |
id | pubmed-7344524 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-73445242020-07-09 Phytochemical Compositions and Biological Activities of Essential Oils from the Leaves, Rhizomes and Whole Plant of Hornstedtia bella Škorničk Donadu, Matthew Gavino Trong Le, Nhan Viet Ho, Duc Quoc Doan, Tuan Tuan Le, Anh Raal, Ain Usai, Marianna Marchetti, Mauro Sanna, Giuseppina Madeddu, Silvia Rappelli, Paola Diaz, Nicia Molicotti, Paola Carta, Antonio Piras, Sandra Usai, Donatella Thi Nguyen, Hoai Cappuccinelli, Piero Zanetti, Stefania Antibiotics (Basel) Article The rapid emergence of drug-resistant strains and novel viruses have motivated the search for new anti-infectious agents. In this study, the chemical compositions and cytotoxicity, as well as the antibacterial, antifungal, antitrichomonas, and antiviral activities of essential oils from the leaves, rhizomes, and whole plant of Hornstedtia bella were investigated. The GC/MS analysis showed that β-pinene, E-β-caryophyllene, and α-humulene were found at high concentrations in the essential oils. The essential oils exhibited (i) inhibition against Staphylococcus aureus, methicillin-resistant Staphylococcus aureus, Staphylococcus epidermidis with minimum inhibitory concentrations (MIC) and minimum lethal concentration (MLC) values from 1 to 4% (v/v); (ii) MIC and MLC values from 2 to 16% (v/v) in Candida tropicalis and Candida parapsilosis; (iii) MIC and MLC values from 4 to 16% in Enterococcus faecalis; and (iv) MIC and MLC values from 8 to greater than or equal to 16% (v/v) in the remaining strains, including Escherichia coli, Pseudomonas aeruginosa, Klebsiella pneumoniae, Candida albicans, and Candida glabrata. In antitrichomonas activity, the leaves and whole-plant oils of Hornstedtia bella possessed IC(50), IC(90), and MLC values of 0.008%, 0.016%, and 0.03% (v/v), respectively, whilst those of rhizomes oil had in turn, 0.004%, 0.008%, and 0.016% (v/v).Besides, the leaf oil showed a weak cytotoxicity against Vero 76 and MRC-5; meanwhile, rhizomes and whole-plant oils did not exert any toxic effects on cell monolayers. Finally, these oils were not active against EV-A71. MDPI 2020-06-18 /pmc/articles/PMC7344524/ /pubmed/32570731 http://dx.doi.org/10.3390/antibiotics9060334 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Donadu, Matthew Gavino Trong Le, Nhan Viet Ho, Duc Quoc Doan, Tuan Tuan Le, Anh Raal, Ain Usai, Marianna Marchetti, Mauro Sanna, Giuseppina Madeddu, Silvia Rappelli, Paola Diaz, Nicia Molicotti, Paola Carta, Antonio Piras, Sandra Usai, Donatella Thi Nguyen, Hoai Cappuccinelli, Piero Zanetti, Stefania Phytochemical Compositions and Biological Activities of Essential Oils from the Leaves, Rhizomes and Whole Plant of Hornstedtia bella Škorničk |
title | Phytochemical Compositions and Biological Activities of Essential Oils from the Leaves, Rhizomes and Whole Plant of Hornstedtia bella Škorničk |
title_full | Phytochemical Compositions and Biological Activities of Essential Oils from the Leaves, Rhizomes and Whole Plant of Hornstedtia bella Škorničk |
title_fullStr | Phytochemical Compositions and Biological Activities of Essential Oils from the Leaves, Rhizomes and Whole Plant of Hornstedtia bella Škorničk |
title_full_unstemmed | Phytochemical Compositions and Biological Activities of Essential Oils from the Leaves, Rhizomes and Whole Plant of Hornstedtia bella Škorničk |
title_short | Phytochemical Compositions and Biological Activities of Essential Oils from the Leaves, Rhizomes and Whole Plant of Hornstedtia bella Škorničk |
title_sort | phytochemical compositions and biological activities of essential oils from the leaves, rhizomes and whole plant of hornstedtia bella škorničk |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7344524/ https://www.ncbi.nlm.nih.gov/pubmed/32570731 http://dx.doi.org/10.3390/antibiotics9060334 |
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