Synthesis and Anti-Saprolegnia Activity of New 2’,4’-Dihydroxydihydrochalcone Derivatives

In the present study, seven 2’,4’-dihydroxydihydrochalcone derivatives (compounds 3–9) were synthesized and their capacity as anti-Saprolegnia agents were evaluated against Saprolegnia parasitica, S. australis, S. diclina. Derivative 9 showed the best activity against the different strains, with min...

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Detalles Bibliográficos
Autores principales: Werner, Enrique, Montenegro, Iván, Said, Bastian, Godoy, Patricio, Besoain, Ximena, Caro, Nelson, Madrid, Alejandro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7344530/
https://www.ncbi.nlm.nih.gov/pubmed/32532060
http://dx.doi.org/10.3390/antibiotics9060317
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author Werner, Enrique
Montenegro, Iván
Said, Bastian
Godoy, Patricio
Besoain, Ximena
Caro, Nelson
Madrid, Alejandro
author_facet Werner, Enrique
Montenegro, Iván
Said, Bastian
Godoy, Patricio
Besoain, Ximena
Caro, Nelson
Madrid, Alejandro
author_sort Werner, Enrique
collection PubMed
description In the present study, seven 2’,4’-dihydroxydihydrochalcone derivatives (compounds 3–9) were synthesized and their capacity as anti-Saprolegnia agents were evaluated against Saprolegnia parasitica, S. australis, S. diclina. Derivative 9 showed the best activity against the different strains, with minimum inhibitory concentration (MIC) and minimum oomyceticidal concentration (MOC) values between 100–175 μg/mL and 100–200 μg/mL, respectively, compared with bronopol and fluconazole as positive controls. In addition, compound 9 caused damage and disintegration cell membrane of all Saprolegnia strains over the action of commercial controls.
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spelling pubmed-73445302020-07-09 Synthesis and Anti-Saprolegnia Activity of New 2’,4’-Dihydroxydihydrochalcone Derivatives Werner, Enrique Montenegro, Iván Said, Bastian Godoy, Patricio Besoain, Ximena Caro, Nelson Madrid, Alejandro Antibiotics (Basel) Communication In the present study, seven 2’,4’-dihydroxydihydrochalcone derivatives (compounds 3–9) were synthesized and their capacity as anti-Saprolegnia agents were evaluated against Saprolegnia parasitica, S. australis, S. diclina. Derivative 9 showed the best activity against the different strains, with minimum inhibitory concentration (MIC) and minimum oomyceticidal concentration (MOC) values between 100–175 μg/mL and 100–200 μg/mL, respectively, compared with bronopol and fluconazole as positive controls. In addition, compound 9 caused damage and disintegration cell membrane of all Saprolegnia strains over the action of commercial controls. MDPI 2020-06-10 /pmc/articles/PMC7344530/ /pubmed/32532060 http://dx.doi.org/10.3390/antibiotics9060317 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Communication
Werner, Enrique
Montenegro, Iván
Said, Bastian
Godoy, Patricio
Besoain, Ximena
Caro, Nelson
Madrid, Alejandro
Synthesis and Anti-Saprolegnia Activity of New 2’,4’-Dihydroxydihydrochalcone Derivatives
title Synthesis and Anti-Saprolegnia Activity of New 2’,4’-Dihydroxydihydrochalcone Derivatives
title_full Synthesis and Anti-Saprolegnia Activity of New 2’,4’-Dihydroxydihydrochalcone Derivatives
title_fullStr Synthesis and Anti-Saprolegnia Activity of New 2’,4’-Dihydroxydihydrochalcone Derivatives
title_full_unstemmed Synthesis and Anti-Saprolegnia Activity of New 2’,4’-Dihydroxydihydrochalcone Derivatives
title_short Synthesis and Anti-Saprolegnia Activity of New 2’,4’-Dihydroxydihydrochalcone Derivatives
title_sort synthesis and anti-saprolegnia activity of new 2’,4’-dihydroxydihydrochalcone derivatives
topic Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7344530/
https://www.ncbi.nlm.nih.gov/pubmed/32532060
http://dx.doi.org/10.3390/antibiotics9060317
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