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Revisiting the Impact of Neurodegenerative Proteins in Epilepsy: Focus on Alpha-Synuclein, Beta-Amyloid, and Tau

Lack of disease-modifying therapy against epileptogenesis reflects the complexity of the disease pathogenesis as well as the high demand to explore novel treatment strategies. In the pursuit of developing new therapeutic strategies against epileptogenesis, neurodegenerative proteins have recently ga...

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Detalles Bibliográficos
Autores principales: Paudel, Yam Nath, Angelopoulou, Efthalia, Piperi, Christina, Othman, Iekhsan, Shaikh, Mohd. Farooq
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7344698/
https://www.ncbi.nlm.nih.gov/pubmed/32545604
http://dx.doi.org/10.3390/biology9060122
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author Paudel, Yam Nath
Angelopoulou, Efthalia
Piperi, Christina
Othman, Iekhsan
Shaikh, Mohd. Farooq
author_facet Paudel, Yam Nath
Angelopoulou, Efthalia
Piperi, Christina
Othman, Iekhsan
Shaikh, Mohd. Farooq
author_sort Paudel, Yam Nath
collection PubMed
description Lack of disease-modifying therapy against epileptogenesis reflects the complexity of the disease pathogenesis as well as the high demand to explore novel treatment strategies. In the pursuit of developing new therapeutic strategies against epileptogenesis, neurodegenerative proteins have recently gained increased attention. Owing to the fact that neurodegenerative disease and epileptogenesis possibly share a common underlying mechanism, targeting neurodegenerative proteins against epileptogenesis might represent a promising therapeutic approach. Herein, we review the association of neurodegenerative proteins, such as α-synuclein, amyloid-beta (Aβ), and tau protein, with epilepsy. Providing insight into the α-synuclein, Aβ and tau protein-mediated neurodegeneration mechanisms, and their implication in epileptogenesis will pave the way towards the development of new agents and treatment strategies.
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spelling pubmed-73446982020-07-09 Revisiting the Impact of Neurodegenerative Proteins in Epilepsy: Focus on Alpha-Synuclein, Beta-Amyloid, and Tau Paudel, Yam Nath Angelopoulou, Efthalia Piperi, Christina Othman, Iekhsan Shaikh, Mohd. Farooq Biology (Basel) Review Lack of disease-modifying therapy against epileptogenesis reflects the complexity of the disease pathogenesis as well as the high demand to explore novel treatment strategies. In the pursuit of developing new therapeutic strategies against epileptogenesis, neurodegenerative proteins have recently gained increased attention. Owing to the fact that neurodegenerative disease and epileptogenesis possibly share a common underlying mechanism, targeting neurodegenerative proteins against epileptogenesis might represent a promising therapeutic approach. Herein, we review the association of neurodegenerative proteins, such as α-synuclein, amyloid-beta (Aβ), and tau protein, with epilepsy. Providing insight into the α-synuclein, Aβ and tau protein-mediated neurodegeneration mechanisms, and their implication in epileptogenesis will pave the way towards the development of new agents and treatment strategies. MDPI 2020-06-12 /pmc/articles/PMC7344698/ /pubmed/32545604 http://dx.doi.org/10.3390/biology9060122 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Paudel, Yam Nath
Angelopoulou, Efthalia
Piperi, Christina
Othman, Iekhsan
Shaikh, Mohd. Farooq
Revisiting the Impact of Neurodegenerative Proteins in Epilepsy: Focus on Alpha-Synuclein, Beta-Amyloid, and Tau
title Revisiting the Impact of Neurodegenerative Proteins in Epilepsy: Focus on Alpha-Synuclein, Beta-Amyloid, and Tau
title_full Revisiting the Impact of Neurodegenerative Proteins in Epilepsy: Focus on Alpha-Synuclein, Beta-Amyloid, and Tau
title_fullStr Revisiting the Impact of Neurodegenerative Proteins in Epilepsy: Focus on Alpha-Synuclein, Beta-Amyloid, and Tau
title_full_unstemmed Revisiting the Impact of Neurodegenerative Proteins in Epilepsy: Focus on Alpha-Synuclein, Beta-Amyloid, and Tau
title_short Revisiting the Impact of Neurodegenerative Proteins in Epilepsy: Focus on Alpha-Synuclein, Beta-Amyloid, and Tau
title_sort revisiting the impact of neurodegenerative proteins in epilepsy: focus on alpha-synuclein, beta-amyloid, and tau
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7344698/
https://www.ncbi.nlm.nih.gov/pubmed/32545604
http://dx.doi.org/10.3390/biology9060122
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