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Review of Oxepine-Pyrimidinone-Ketopiperazine Type Nonribosomal Peptides
Recently, a rare class of nonribosomal peptides (NRPs) bearing a unique Oxepine-Pyrimidinone-Ketopiperazine (OPK) scaffold has been exclusively isolated from fungal sources. Based on the number of rings and conjugation systems on the backbone, it can be further categorized into three types A, B, and...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7344746/ https://www.ncbi.nlm.nih.gov/pubmed/32549308 http://dx.doi.org/10.3390/metabo10060246 |
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author | Guo, Yaojie Frisvad, Jens C. Larsen, Thomas O. |
author_facet | Guo, Yaojie Frisvad, Jens C. Larsen, Thomas O. |
author_sort | Guo, Yaojie |
collection | PubMed |
description | Recently, a rare class of nonribosomal peptides (NRPs) bearing a unique Oxepine-Pyrimidinone-Ketopiperazine (OPK) scaffold has been exclusively isolated from fungal sources. Based on the number of rings and conjugation systems on the backbone, it can be further categorized into three types A, B, and C. These compounds have been applied to various bioassays, and some have exhibited promising bioactivities like antifungal activity against phytopathogenic fungi and transcriptional activation on liver X receptor α. This review summarizes all the research related to natural OPK NRPs, including their biological sources, chemical structures, bioassays, as well as proposed biosynthetic mechanisms from 1988 to March 2020. The taxonomy of the fungal sources and chirality-related issues of these products are also discussed. |
format | Online Article Text |
id | pubmed-7344746 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-73447462020-07-09 Review of Oxepine-Pyrimidinone-Ketopiperazine Type Nonribosomal Peptides Guo, Yaojie Frisvad, Jens C. Larsen, Thomas O. Metabolites Review Recently, a rare class of nonribosomal peptides (NRPs) bearing a unique Oxepine-Pyrimidinone-Ketopiperazine (OPK) scaffold has been exclusively isolated from fungal sources. Based on the number of rings and conjugation systems on the backbone, it can be further categorized into three types A, B, and C. These compounds have been applied to various bioassays, and some have exhibited promising bioactivities like antifungal activity against phytopathogenic fungi and transcriptional activation on liver X receptor α. This review summarizes all the research related to natural OPK NRPs, including their biological sources, chemical structures, bioassays, as well as proposed biosynthetic mechanisms from 1988 to March 2020. The taxonomy of the fungal sources and chirality-related issues of these products are also discussed. MDPI 2020-06-15 /pmc/articles/PMC7344746/ /pubmed/32549308 http://dx.doi.org/10.3390/metabo10060246 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Guo, Yaojie Frisvad, Jens C. Larsen, Thomas O. Review of Oxepine-Pyrimidinone-Ketopiperazine Type Nonribosomal Peptides |
title | Review of Oxepine-Pyrimidinone-Ketopiperazine Type Nonribosomal Peptides |
title_full | Review of Oxepine-Pyrimidinone-Ketopiperazine Type Nonribosomal Peptides |
title_fullStr | Review of Oxepine-Pyrimidinone-Ketopiperazine Type Nonribosomal Peptides |
title_full_unstemmed | Review of Oxepine-Pyrimidinone-Ketopiperazine Type Nonribosomal Peptides |
title_short | Review of Oxepine-Pyrimidinone-Ketopiperazine Type Nonribosomal Peptides |
title_sort | review of oxepine-pyrimidinone-ketopiperazine type nonribosomal peptides |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7344746/ https://www.ncbi.nlm.nih.gov/pubmed/32549308 http://dx.doi.org/10.3390/metabo10060246 |
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