Halosmysin A, a Novel 14-Membered Macrodiolide Isolated from the Marine-Algae-Derived Fungus Halosphaeriaceae sp.

Halosmysin A, a new 14-membered macrodiolide with an unprecedented skeleton, was isolated from the fungus Halosphaeriaceae sp. OUPS-135D-4, which, in turn, was obtained from the marine algae Sargassum thunbergii. The chemical structure of the macrodiolide was elucidated using 1D and 2D NMR, as well...

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Autores principales: Yamada, Takeshi, Kogure, Haruka, Kataoka, Minami, Kikuchi, Takashi, Hirano, Tomoya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7344848/
https://www.ncbi.nlm.nih.gov/pubmed/32570727
http://dx.doi.org/10.3390/md18060320
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author Yamada, Takeshi
Kogure, Haruka
Kataoka, Minami
Kikuchi, Takashi
Hirano, Tomoya
author_facet Yamada, Takeshi
Kogure, Haruka
Kataoka, Minami
Kikuchi, Takashi
Hirano, Tomoya
author_sort Yamada, Takeshi
collection PubMed
description Halosmysin A, a new 14-membered macrodiolide with an unprecedented skeleton, was isolated from the fungus Halosphaeriaceae sp. OUPS-135D-4, which, in turn, was obtained from the marine algae Sargassum thunbergii. The chemical structure of the macrodiolide was elucidated using 1D and 2D NMR, as well as high resolution fast atom bombardment mass (HRFABMS) spectral analysis. The absolute stereochemistry was determined via chemical derivatization and comparison with a known compound, (6R,11R,12R,14R)-colletodiol. Additionally, halosmysin A was shown to be very potent against murine P388 leukemia, human HL-60 leukemia, and murine L1210 leukemia cell lines, with IC(50) values ranging from 2.2 ± 3.1 to 11.7 ± 2.8 μM.
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spelling pubmed-73448482020-07-09 Halosmysin A, a Novel 14-Membered Macrodiolide Isolated from the Marine-Algae-Derived Fungus Halosphaeriaceae sp. Yamada, Takeshi Kogure, Haruka Kataoka, Minami Kikuchi, Takashi Hirano, Tomoya Mar Drugs Article Halosmysin A, a new 14-membered macrodiolide with an unprecedented skeleton, was isolated from the fungus Halosphaeriaceae sp. OUPS-135D-4, which, in turn, was obtained from the marine algae Sargassum thunbergii. The chemical structure of the macrodiolide was elucidated using 1D and 2D NMR, as well as high resolution fast atom bombardment mass (HRFABMS) spectral analysis. The absolute stereochemistry was determined via chemical derivatization and comparison with a known compound, (6R,11R,12R,14R)-colletodiol. Additionally, halosmysin A was shown to be very potent against murine P388 leukemia, human HL-60 leukemia, and murine L1210 leukemia cell lines, with IC(50) values ranging from 2.2 ± 3.1 to 11.7 ± 2.8 μM. MDPI 2020-06-18 /pmc/articles/PMC7344848/ /pubmed/32570727 http://dx.doi.org/10.3390/md18060320 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Yamada, Takeshi
Kogure, Haruka
Kataoka, Minami
Kikuchi, Takashi
Hirano, Tomoya
Halosmysin A, a Novel 14-Membered Macrodiolide Isolated from the Marine-Algae-Derived Fungus Halosphaeriaceae sp.
title Halosmysin A, a Novel 14-Membered Macrodiolide Isolated from the Marine-Algae-Derived Fungus Halosphaeriaceae sp.
title_full Halosmysin A, a Novel 14-Membered Macrodiolide Isolated from the Marine-Algae-Derived Fungus Halosphaeriaceae sp.
title_fullStr Halosmysin A, a Novel 14-Membered Macrodiolide Isolated from the Marine-Algae-Derived Fungus Halosphaeriaceae sp.
title_full_unstemmed Halosmysin A, a Novel 14-Membered Macrodiolide Isolated from the Marine-Algae-Derived Fungus Halosphaeriaceae sp.
title_short Halosmysin A, a Novel 14-Membered Macrodiolide Isolated from the Marine-Algae-Derived Fungus Halosphaeriaceae sp.
title_sort halosmysin a, a novel 14-membered macrodiolide isolated from the marine-algae-derived fungus halosphaeriaceae sp.
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7344848/
https://www.ncbi.nlm.nih.gov/pubmed/32570727
http://dx.doi.org/10.3390/md18060320
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