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Investigating Cardiac Morphological Alterations in a Pentylenetetrazol-Kindling Model of Epilepsy

Epilepsy is a group of neurological disorders characterized by abnormal electrical activity in the central nervous system (CNS) and recurrent seizures representing the principal clinical manifestation. Sudden unexpected death in epilepsy (SUDEP) is the predominant cause of death in young epileptic p...

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Autores principales: Akyuz, Enes, Polat, Kristina, Ates, Sukru, Unalmis, Demet, Tokpinar, Adem, Yilmaz, Seher, Kaymak, Emin, Doganyigit, Zuleyha, Villa, Chiara
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7344915/
https://www.ncbi.nlm.nih.gov/pubmed/32526953
http://dx.doi.org/10.3390/diagnostics10060388
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author Akyuz, Enes
Polat, Kristina
Ates, Sukru
Unalmis, Demet
Tokpinar, Adem
Yilmaz, Seher
Kaymak, Emin
Doganyigit, Zuleyha
Villa, Chiara
author_facet Akyuz, Enes
Polat, Kristina
Ates, Sukru
Unalmis, Demet
Tokpinar, Adem
Yilmaz, Seher
Kaymak, Emin
Doganyigit, Zuleyha
Villa, Chiara
author_sort Akyuz, Enes
collection PubMed
description Epilepsy is a group of neurological disorders characterized by abnormal electrical activity in the central nervous system (CNS) and recurrent seizures representing the principal clinical manifestation. Sudden unexpected death in epilepsy (SUDEP) is the predominant cause of death in young epileptic patients. SUDEP patients displayed an increased cardiovascular (CV) risk, probably due to an impaired autonomic control of CV functions, but the underlying mechanisms need to be explored yet. Therefore, we aimed to examine the cardiac morphological alterations in a pentylenetetrazol (PTZ)-kindled rat model, a well-established tool for studying chronic epilepsy. To complete this, the distance between the atria, between the atrium and ventricle were measured, the heart was weighed, and the pathological morphology of dissected hearts was analyzed by histological assessment with hematoxylin and eosin staining. A significantly decreased distance between atria and a significant increase in heart weight were observed in PTZ-kindled rats which interestingly also displayed increased hemorrhagic content when compared with controls. Our findings provided evidence that changes in cardiac morphology may be related to autonomic CV dysfunctions occurring during SUDEP while also opening up more avenues to better develop novel drugs for the treatment of this disorder.
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spelling pubmed-73449152020-07-09 Investigating Cardiac Morphological Alterations in a Pentylenetetrazol-Kindling Model of Epilepsy Akyuz, Enes Polat, Kristina Ates, Sukru Unalmis, Demet Tokpinar, Adem Yilmaz, Seher Kaymak, Emin Doganyigit, Zuleyha Villa, Chiara Diagnostics (Basel) Article Epilepsy is a group of neurological disorders characterized by abnormal electrical activity in the central nervous system (CNS) and recurrent seizures representing the principal clinical manifestation. Sudden unexpected death in epilepsy (SUDEP) is the predominant cause of death in young epileptic patients. SUDEP patients displayed an increased cardiovascular (CV) risk, probably due to an impaired autonomic control of CV functions, but the underlying mechanisms need to be explored yet. Therefore, we aimed to examine the cardiac morphological alterations in a pentylenetetrazol (PTZ)-kindled rat model, a well-established tool for studying chronic epilepsy. To complete this, the distance between the atria, between the atrium and ventricle were measured, the heart was weighed, and the pathological morphology of dissected hearts was analyzed by histological assessment with hematoxylin and eosin staining. A significantly decreased distance between atria and a significant increase in heart weight were observed in PTZ-kindled rats which interestingly also displayed increased hemorrhagic content when compared with controls. Our findings provided evidence that changes in cardiac morphology may be related to autonomic CV dysfunctions occurring during SUDEP while also opening up more avenues to better develop novel drugs for the treatment of this disorder. MDPI 2020-06-09 /pmc/articles/PMC7344915/ /pubmed/32526953 http://dx.doi.org/10.3390/diagnostics10060388 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Akyuz, Enes
Polat, Kristina
Ates, Sukru
Unalmis, Demet
Tokpinar, Adem
Yilmaz, Seher
Kaymak, Emin
Doganyigit, Zuleyha
Villa, Chiara
Investigating Cardiac Morphological Alterations in a Pentylenetetrazol-Kindling Model of Epilepsy
title Investigating Cardiac Morphological Alterations in a Pentylenetetrazol-Kindling Model of Epilepsy
title_full Investigating Cardiac Morphological Alterations in a Pentylenetetrazol-Kindling Model of Epilepsy
title_fullStr Investigating Cardiac Morphological Alterations in a Pentylenetetrazol-Kindling Model of Epilepsy
title_full_unstemmed Investigating Cardiac Morphological Alterations in a Pentylenetetrazol-Kindling Model of Epilepsy
title_short Investigating Cardiac Morphological Alterations in a Pentylenetetrazol-Kindling Model of Epilepsy
title_sort investigating cardiac morphological alterations in a pentylenetetrazol-kindling model of epilepsy
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7344915/
https://www.ncbi.nlm.nih.gov/pubmed/32526953
http://dx.doi.org/10.3390/diagnostics10060388
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