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Inhibition of Skin Inflammation by Scytonemin, an Ultraviolet Sunscreen Pigment

Scytonemin is a yellow-green ultraviolet sunscreen pigment present in different genera of aquatic and terrestrial blue-green algae, including marine cyanobacteria. In the present study, the anti-inflammatory activities of scytonemin were evaluated in vitro and in vivo. Topical application of scytone...

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Autores principales: Kang, Moo Rim, Jo, Sun Ah, Lee, Hyunju, Yoon, Yeo Dae, Kwon, Joo-Hee, Yang, Jeong-Wook, Choi, Byeong Jo, Park, Ki Hwan, Lee, Myeong Youl, Lee, Chang Woo, Lee, Kyeong-Ryoon, Kang, Jong Soon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7344946/
https://www.ncbi.nlm.nih.gov/pubmed/32512874
http://dx.doi.org/10.3390/md18060300
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author Kang, Moo Rim
Jo, Sun Ah
Lee, Hyunju
Yoon, Yeo Dae
Kwon, Joo-Hee
Yang, Jeong-Wook
Choi, Byeong Jo
Park, Ki Hwan
Lee, Myeong Youl
Lee, Chang Woo
Lee, Kyeong-Ryoon
Kang, Jong Soon
author_facet Kang, Moo Rim
Jo, Sun Ah
Lee, Hyunju
Yoon, Yeo Dae
Kwon, Joo-Hee
Yang, Jeong-Wook
Choi, Byeong Jo
Park, Ki Hwan
Lee, Myeong Youl
Lee, Chang Woo
Lee, Kyeong-Ryoon
Kang, Jong Soon
author_sort Kang, Moo Rim
collection PubMed
description Scytonemin is a yellow-green ultraviolet sunscreen pigment present in different genera of aquatic and terrestrial blue-green algae, including marine cyanobacteria. In the present study, the anti-inflammatory activities of scytonemin were evaluated in vitro and in vivo. Topical application of scytonemin inhibited 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced ear swelling in BALB/c mice. The expression of tumor necrosis factor-α (TNF-α) and inducible nitric oxide synthase (iNOS) was also suppressed by scytonemin treatment in the TPA-treated ear of BALB/c mice. In addition, scytonemin inhibited lipopolysaccharide (LPS)-induced production of TNF-α and nitric oxide (NO) in RAW 264.7 cells, a murine macrophage-like cell line, and the mRNA expressions of TNF-α and iNOS were also suppressed by scytonemin in LPS-stimulated RAW 264.7 cells. Further study demonstrated that LPS-induced NF-κB activity was significantly suppressed by scytonemin treatment in RAW 264.7 cells. Our results also showed that the degradation of IκBα and nuclear translocation of the p65 subunit were blocked by scytonemin in LPS-stimulated RAW 264.7 cells. Collectively, these results suggest that scytonemin inhibits skin inflammation by blocking the expression of inflammatory mediators, and the anti-inflammatory effect of scytonemin is mediated, at least in part, by down-regulation of NF-κB activity. Our results also suggest that scytonemin might be used as a multi-function skin care ingredient for UV protection and anti-inflammation.
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spelling pubmed-73449462020-07-09 Inhibition of Skin Inflammation by Scytonemin, an Ultraviolet Sunscreen Pigment Kang, Moo Rim Jo, Sun Ah Lee, Hyunju Yoon, Yeo Dae Kwon, Joo-Hee Yang, Jeong-Wook Choi, Byeong Jo Park, Ki Hwan Lee, Myeong Youl Lee, Chang Woo Lee, Kyeong-Ryoon Kang, Jong Soon Mar Drugs Article Scytonemin is a yellow-green ultraviolet sunscreen pigment present in different genera of aquatic and terrestrial blue-green algae, including marine cyanobacteria. In the present study, the anti-inflammatory activities of scytonemin were evaluated in vitro and in vivo. Topical application of scytonemin inhibited 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced ear swelling in BALB/c mice. The expression of tumor necrosis factor-α (TNF-α) and inducible nitric oxide synthase (iNOS) was also suppressed by scytonemin treatment in the TPA-treated ear of BALB/c mice. In addition, scytonemin inhibited lipopolysaccharide (LPS)-induced production of TNF-α and nitric oxide (NO) in RAW 264.7 cells, a murine macrophage-like cell line, and the mRNA expressions of TNF-α and iNOS were also suppressed by scytonemin in LPS-stimulated RAW 264.7 cells. Further study demonstrated that LPS-induced NF-κB activity was significantly suppressed by scytonemin treatment in RAW 264.7 cells. Our results also showed that the degradation of IκBα and nuclear translocation of the p65 subunit were blocked by scytonemin in LPS-stimulated RAW 264.7 cells. Collectively, these results suggest that scytonemin inhibits skin inflammation by blocking the expression of inflammatory mediators, and the anti-inflammatory effect of scytonemin is mediated, at least in part, by down-regulation of NF-κB activity. Our results also suggest that scytonemin might be used as a multi-function skin care ingredient for UV protection and anti-inflammation. MDPI 2020-06-04 /pmc/articles/PMC7344946/ /pubmed/32512874 http://dx.doi.org/10.3390/md18060300 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Kang, Moo Rim
Jo, Sun Ah
Lee, Hyunju
Yoon, Yeo Dae
Kwon, Joo-Hee
Yang, Jeong-Wook
Choi, Byeong Jo
Park, Ki Hwan
Lee, Myeong Youl
Lee, Chang Woo
Lee, Kyeong-Ryoon
Kang, Jong Soon
Inhibition of Skin Inflammation by Scytonemin, an Ultraviolet Sunscreen Pigment
title Inhibition of Skin Inflammation by Scytonemin, an Ultraviolet Sunscreen Pigment
title_full Inhibition of Skin Inflammation by Scytonemin, an Ultraviolet Sunscreen Pigment
title_fullStr Inhibition of Skin Inflammation by Scytonemin, an Ultraviolet Sunscreen Pigment
title_full_unstemmed Inhibition of Skin Inflammation by Scytonemin, an Ultraviolet Sunscreen Pigment
title_short Inhibition of Skin Inflammation by Scytonemin, an Ultraviolet Sunscreen Pigment
title_sort inhibition of skin inflammation by scytonemin, an ultraviolet sunscreen pigment
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7344946/
https://www.ncbi.nlm.nih.gov/pubmed/32512874
http://dx.doi.org/10.3390/md18060300
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