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Antimycobacterial Activity of Laurinterol and Aplysin from Laurencia johnstonii

Marine environments represent a great opportunity for the discovery of compounds with a wide spectrum of bioactive properties. Due to their large variety and functions derived from natural selection, marine natural products may allow the identification of novel drugs based not only on newly discover...

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Autores principales: García-Davis, Sara, Leal-López, Karla, Molina-Torres, Carmen A., Vera-Cabrera, Lucio, Díaz-Marrero, Ana R., Fernández, José J., Carranza-Rosales, Pilar, Viveros-Valdez, Ezequiel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7345040/
https://www.ncbi.nlm.nih.gov/pubmed/32486286
http://dx.doi.org/10.3390/md18060287
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author García-Davis, Sara
Leal-López, Karla
Molina-Torres, Carmen A.
Vera-Cabrera, Lucio
Díaz-Marrero, Ana R.
Fernández, José J.
Carranza-Rosales, Pilar
Viveros-Valdez, Ezequiel
author_facet García-Davis, Sara
Leal-López, Karla
Molina-Torres, Carmen A.
Vera-Cabrera, Lucio
Díaz-Marrero, Ana R.
Fernández, José J.
Carranza-Rosales, Pilar
Viveros-Valdez, Ezequiel
author_sort García-Davis, Sara
collection PubMed
description Marine environments represent a great opportunity for the discovery of compounds with a wide spectrum of bioactive properties. Due to their large variety and functions derived from natural selection, marine natural products may allow the identification of novel drugs based not only on newly discovered bioactive metabolites but also on already known compounds not yet thoroughly investigated. Since drug resistance has caused an increase in infections by Mycobacterium tuberculosis and nontuberculous mycobacteria, the re-evaluation of known bioactive metabolites has been suggested as a good approach to addressing this problem. In this sense, this study presents an evaluation of the in vitro effect of laurinterol and aplysin, two brominated sesquiterpenes isolated from Laurencia johnstonii, against nine M. tuberculosis strains and six nontuberculous mycobacteria (NTM). Laurinterol exhibited good antimycobacterial activity, especially against nontuberculous mycobacteria, being remarkable its effect against Mycobacterium abscessus, with minimum inhibitory concentration (MIC) values lower than those of the reference drug imipenem. This study provides further evidence for the antimycobacterial activity of some sesquiterpenes from L. johnstonii, which can be considered interesting lead compounds for the discovery of novel molecules to treat NTM infections.
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spelling pubmed-73450402020-07-09 Antimycobacterial Activity of Laurinterol and Aplysin from Laurencia johnstonii García-Davis, Sara Leal-López, Karla Molina-Torres, Carmen A. Vera-Cabrera, Lucio Díaz-Marrero, Ana R. Fernández, José J. Carranza-Rosales, Pilar Viveros-Valdez, Ezequiel Mar Drugs Communication Marine environments represent a great opportunity for the discovery of compounds with a wide spectrum of bioactive properties. Due to their large variety and functions derived from natural selection, marine natural products may allow the identification of novel drugs based not only on newly discovered bioactive metabolites but also on already known compounds not yet thoroughly investigated. Since drug resistance has caused an increase in infections by Mycobacterium tuberculosis and nontuberculous mycobacteria, the re-evaluation of known bioactive metabolites has been suggested as a good approach to addressing this problem. In this sense, this study presents an evaluation of the in vitro effect of laurinterol and aplysin, two brominated sesquiterpenes isolated from Laurencia johnstonii, against nine M. tuberculosis strains and six nontuberculous mycobacteria (NTM). Laurinterol exhibited good antimycobacterial activity, especially against nontuberculous mycobacteria, being remarkable its effect against Mycobacterium abscessus, with minimum inhibitory concentration (MIC) values lower than those of the reference drug imipenem. This study provides further evidence for the antimycobacterial activity of some sesquiterpenes from L. johnstonii, which can be considered interesting lead compounds for the discovery of novel molecules to treat NTM infections. MDPI 2020-05-30 /pmc/articles/PMC7345040/ /pubmed/32486286 http://dx.doi.org/10.3390/md18060287 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Communication
García-Davis, Sara
Leal-López, Karla
Molina-Torres, Carmen A.
Vera-Cabrera, Lucio
Díaz-Marrero, Ana R.
Fernández, José J.
Carranza-Rosales, Pilar
Viveros-Valdez, Ezequiel
Antimycobacterial Activity of Laurinterol and Aplysin from Laurencia johnstonii
title Antimycobacterial Activity of Laurinterol and Aplysin from Laurencia johnstonii
title_full Antimycobacterial Activity of Laurinterol and Aplysin from Laurencia johnstonii
title_fullStr Antimycobacterial Activity of Laurinterol and Aplysin from Laurencia johnstonii
title_full_unstemmed Antimycobacterial Activity of Laurinterol and Aplysin from Laurencia johnstonii
title_short Antimycobacterial Activity of Laurinterol and Aplysin from Laurencia johnstonii
title_sort antimycobacterial activity of laurinterol and aplysin from laurencia johnstonii
topic Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7345040/
https://www.ncbi.nlm.nih.gov/pubmed/32486286
http://dx.doi.org/10.3390/md18060287
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