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Laboratory Diagnostics of Rickettsia Infections in Denmark 2008–2015
Rickettsiosis is a vector-borne disease caused by bacterial species in the genus Rickettsia. Ticks in Scandinavia are reported to be infected with Rickettsia, yet only a few Scandinavian human cases are described, and rickettsiosis is poorly understood. The aim of this study was to determine the pre...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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MDPI
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7345066/ https://www.ncbi.nlm.nih.gov/pubmed/32575502 http://dx.doi.org/10.3390/biology9060133 |
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author | Schjørring, Susanne Jepsen, Martin Tugwell Sørensen, Camilla Adler Valentiner-Branth, Palle Kantsø, Bjørn Petersen, Randi Føns Skovgaard, Ole Krogfelt, Karen A. |
author_facet | Schjørring, Susanne Jepsen, Martin Tugwell Sørensen, Camilla Adler Valentiner-Branth, Palle Kantsø, Bjørn Petersen, Randi Føns Skovgaard, Ole Krogfelt, Karen A. |
author_sort | Schjørring, Susanne |
collection | PubMed |
description | Rickettsiosis is a vector-borne disease caused by bacterial species in the genus Rickettsia. Ticks in Scandinavia are reported to be infected with Rickettsia, yet only a few Scandinavian human cases are described, and rickettsiosis is poorly understood. The aim of this study was to determine the prevalence of rickettsiosis in Denmark based on laboratory findings. We found that in the Danish individuals who tested positive for Rickettsia by serology, the majority (86%; 484/561) of the infections belonged to the spotted fever group. In contrast, we could confirm 13 of 41 (32%) PCR-positive individuals by sequencing and identified all of these as R. africae, indicating infections after travel exposure. These 13 samples were collected from wound/skin material. In Denmark, approximately 85 individuals test positive for Rickettsia spp. annually, giving an estimated 26% (561/2147) annual prevalence among those suspected of rickettsiosis after tick bites. However, without clinical data and a history of travel exposure, a true estimation of rickettsiosis acquired endemically by tick bites cannot be made. Therefore, we recommend that both clinical data and specific travel exposure be included in a surveillance system of Rickettsia infections. |
format | Online Article Text |
id | pubmed-7345066 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-73450662020-07-09 Laboratory Diagnostics of Rickettsia Infections in Denmark 2008–2015 Schjørring, Susanne Jepsen, Martin Tugwell Sørensen, Camilla Adler Valentiner-Branth, Palle Kantsø, Bjørn Petersen, Randi Føns Skovgaard, Ole Krogfelt, Karen A. Biology (Basel) Article Rickettsiosis is a vector-borne disease caused by bacterial species in the genus Rickettsia. Ticks in Scandinavia are reported to be infected with Rickettsia, yet only a few Scandinavian human cases are described, and rickettsiosis is poorly understood. The aim of this study was to determine the prevalence of rickettsiosis in Denmark based on laboratory findings. We found that in the Danish individuals who tested positive for Rickettsia by serology, the majority (86%; 484/561) of the infections belonged to the spotted fever group. In contrast, we could confirm 13 of 41 (32%) PCR-positive individuals by sequencing and identified all of these as R. africae, indicating infections after travel exposure. These 13 samples were collected from wound/skin material. In Denmark, approximately 85 individuals test positive for Rickettsia spp. annually, giving an estimated 26% (561/2147) annual prevalence among those suspected of rickettsiosis after tick bites. However, without clinical data and a history of travel exposure, a true estimation of rickettsiosis acquired endemically by tick bites cannot be made. Therefore, we recommend that both clinical data and specific travel exposure be included in a surveillance system of Rickettsia infections. MDPI 2020-06-19 /pmc/articles/PMC7345066/ /pubmed/32575502 http://dx.doi.org/10.3390/biology9060133 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Schjørring, Susanne Jepsen, Martin Tugwell Sørensen, Camilla Adler Valentiner-Branth, Palle Kantsø, Bjørn Petersen, Randi Føns Skovgaard, Ole Krogfelt, Karen A. Laboratory Diagnostics of Rickettsia Infections in Denmark 2008–2015 |
title | Laboratory Diagnostics of Rickettsia Infections in Denmark 2008–2015 |
title_full | Laboratory Diagnostics of Rickettsia Infections in Denmark 2008–2015 |
title_fullStr | Laboratory Diagnostics of Rickettsia Infections in Denmark 2008–2015 |
title_full_unstemmed | Laboratory Diagnostics of Rickettsia Infections in Denmark 2008–2015 |
title_short | Laboratory Diagnostics of Rickettsia Infections in Denmark 2008–2015 |
title_sort | laboratory diagnostics of rickettsia infections in denmark 2008–2015 |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7345066/ https://www.ncbi.nlm.nih.gov/pubmed/32575502 http://dx.doi.org/10.3390/biology9060133 |
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