Generation of Monoclonal Antibodies Specific for Native LL37 and Citrullinated LL37 That Discriminate the Two LL37 Forms in the Skin and Circulation of Cutaneous/Systemic Lupus Erythematosus and Rheumatoid Arthritis Patients

Human cathelicidin LL37 is a cationic antimicrobial peptide active against bacteria and viruses and exerting immune modulatory functions. LL37 can be also a target of autoreactive B- and T-lymphocytes in autoimmune settings. Irreversible post-translational modifications, such as citrullination and c...

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Detalles Bibliográficos
Autores principales: Lande, Roberto, Palazzo, Raffaella, Hammel, Philippe, Pietraforte, Immacolata, Surbeck, Isabelle, Gilliet, Michel, Chizzolini, Carlo, Frasca, Loredana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7345132/
https://www.ncbi.nlm.nih.gov/pubmed/32403306
http://dx.doi.org/10.3390/antib9020014

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