Aspergillus fumigatus Protease Alkaline Protease 1 (Alp1): A New Therapeutic Target for Fungal Asthma

We review three recent findings that have fundamentally altered our understanding of causative mechanisms underlying fungal-related asthma. These mechanisms may be partially independent of host inflammatory processes but are strongly dependent upon the actions of Alp1 on lung structural cells. They...

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Detalles Bibliográficos
Autores principales: Druey, Kirk M., McCullough, Morgan, Krishnan, Ramaswamy
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7345148/
https://www.ncbi.nlm.nih.gov/pubmed/32560087
http://dx.doi.org/10.3390/jof6020088
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author Druey, Kirk M.
McCullough, Morgan
Krishnan, Ramaswamy
author_facet Druey, Kirk M.
McCullough, Morgan
Krishnan, Ramaswamy
author_sort Druey, Kirk M.
collection PubMed
description We review three recent findings that have fundamentally altered our understanding of causative mechanisms underlying fungal-related asthma. These mechanisms may be partially independent of host inflammatory processes but are strongly dependent upon the actions of Alp1 on lung structural cells. They entail (i) bronchial epithelial sensing of Alp1; (ii) Alp1-induced airway smooth muscle (ASM) contraction; (iii) Alp1-induced airflow obstruction. Collectively, these mechanisms point to Alp1 as a new target for intervention in fungal asthma.
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spelling pubmed-73451482020-07-09 Aspergillus fumigatus Protease Alkaline Protease 1 (Alp1): A New Therapeutic Target for Fungal Asthma Druey, Kirk M. McCullough, Morgan Krishnan, Ramaswamy J Fungi (Basel) Review We review three recent findings that have fundamentally altered our understanding of causative mechanisms underlying fungal-related asthma. These mechanisms may be partially independent of host inflammatory processes but are strongly dependent upon the actions of Alp1 on lung structural cells. They entail (i) bronchial epithelial sensing of Alp1; (ii) Alp1-induced airway smooth muscle (ASM) contraction; (iii) Alp1-induced airflow obstruction. Collectively, these mechanisms point to Alp1 as a new target for intervention in fungal asthma. MDPI 2020-06-16 /pmc/articles/PMC7345148/ /pubmed/32560087 http://dx.doi.org/10.3390/jof6020088 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Druey, Kirk M.
McCullough, Morgan
Krishnan, Ramaswamy
Aspergillus fumigatus Protease Alkaline Protease 1 (Alp1): A New Therapeutic Target for Fungal Asthma
title Aspergillus fumigatus Protease Alkaline Protease 1 (Alp1): A New Therapeutic Target for Fungal Asthma
title_full Aspergillus fumigatus Protease Alkaline Protease 1 (Alp1): A New Therapeutic Target for Fungal Asthma
title_fullStr Aspergillus fumigatus Protease Alkaline Protease 1 (Alp1): A New Therapeutic Target for Fungal Asthma
title_full_unstemmed Aspergillus fumigatus Protease Alkaline Protease 1 (Alp1): A New Therapeutic Target for Fungal Asthma
title_short Aspergillus fumigatus Protease Alkaline Protease 1 (Alp1): A New Therapeutic Target for Fungal Asthma
title_sort aspergillus fumigatus protease alkaline protease 1 (alp1): a new therapeutic target for fungal asthma
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7345148/
https://www.ncbi.nlm.nih.gov/pubmed/32560087
http://dx.doi.org/10.3390/jof6020088
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AT krishnanramaswamy aspergillusfumigatusproteasealkalineprotease1alp1anewtherapeutictargetforfungalasthma

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