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Evaluation of BDNF as a Biomarker for Impulsivity in a Psychiatric Population

Impulsivity is an important risk factor for suicide and therefore, identifying biomarkers associated with impulsivity could be important in evaluating psychiatric patients. Currently, assessment of impulsivity is based solely on clinical evaluation. In this study, brain-derived neurotrophic factor (...

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Autores principales: Pasyk, Stanislav, Sanger, Nitika, Kapczinski, Flavio, Samaan, Zainab
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7345173/
https://www.ncbi.nlm.nih.gov/pubmed/32575733
http://dx.doi.org/10.3390/diagnostics10060419
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author Pasyk, Stanislav
Sanger, Nitika
Kapczinski, Flavio
Samaan, Zainab
author_facet Pasyk, Stanislav
Sanger, Nitika
Kapczinski, Flavio
Samaan, Zainab
author_sort Pasyk, Stanislav
collection PubMed
description Impulsivity is an important risk factor for suicide and therefore, identifying biomarkers associated with impulsivity could be important in evaluating psychiatric patients. Currently, assessment of impulsivity is based solely on clinical evaluation. In this study, brain-derived neurotrophic factor (BDNF), a nerve growth factor, was evaluated as a potential biomarker for impulsivity. We hypothesize that elevated BDNF may result in aberrantly high neurobiological activation, promoting impulsive behaviours. A total of 343 participants were recruited for the study and were divided into two groups, (i) elevated suicide risk (participants admitted to hospital with a recent suicide attempt), and (ii) average suicide risk (non-psychiatric participants and psychiatric participants without a history of suicide attempts). Impulsivity was measured by the Barratt Impulsiveness Scale, and serum BDNF levels were obtained. A regression analysis was performed to identify associations between BDNF and impulsivity. We identified a subtle but significant positive association between BDNF and impulsivity in the average risk for suicide group (B = 0.189, p = 0.014). The same association was not reproduced in the elevated risk group B = −0.086, p = 0.361). These findings lay the foundation to further explore the utility of BDNF as a biomarker for impulsivity to allow for early intervention.
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spelling pubmed-73451732020-07-09 Evaluation of BDNF as a Biomarker for Impulsivity in a Psychiatric Population Pasyk, Stanislav Sanger, Nitika Kapczinski, Flavio Samaan, Zainab Diagnostics (Basel) Article Impulsivity is an important risk factor for suicide and therefore, identifying biomarkers associated with impulsivity could be important in evaluating psychiatric patients. Currently, assessment of impulsivity is based solely on clinical evaluation. In this study, brain-derived neurotrophic factor (BDNF), a nerve growth factor, was evaluated as a potential biomarker for impulsivity. We hypothesize that elevated BDNF may result in aberrantly high neurobiological activation, promoting impulsive behaviours. A total of 343 participants were recruited for the study and were divided into two groups, (i) elevated suicide risk (participants admitted to hospital with a recent suicide attempt), and (ii) average suicide risk (non-psychiatric participants and psychiatric participants without a history of suicide attempts). Impulsivity was measured by the Barratt Impulsiveness Scale, and serum BDNF levels were obtained. A regression analysis was performed to identify associations between BDNF and impulsivity. We identified a subtle but significant positive association between BDNF and impulsivity in the average risk for suicide group (B = 0.189, p = 0.014). The same association was not reproduced in the elevated risk group B = −0.086, p = 0.361). These findings lay the foundation to further explore the utility of BDNF as a biomarker for impulsivity to allow for early intervention. MDPI 2020-06-20 /pmc/articles/PMC7345173/ /pubmed/32575733 http://dx.doi.org/10.3390/diagnostics10060419 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Pasyk, Stanislav
Sanger, Nitika
Kapczinski, Flavio
Samaan, Zainab
Evaluation of BDNF as a Biomarker for Impulsivity in a Psychiatric Population
title Evaluation of BDNF as a Biomarker for Impulsivity in a Psychiatric Population
title_full Evaluation of BDNF as a Biomarker for Impulsivity in a Psychiatric Population
title_fullStr Evaluation of BDNF as a Biomarker for Impulsivity in a Psychiatric Population
title_full_unstemmed Evaluation of BDNF as a Biomarker for Impulsivity in a Psychiatric Population
title_short Evaluation of BDNF as a Biomarker for Impulsivity in a Psychiatric Population
title_sort evaluation of bdnf as a biomarker for impulsivity in a psychiatric population
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7345173/
https://www.ncbi.nlm.nih.gov/pubmed/32575733
http://dx.doi.org/10.3390/diagnostics10060419
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