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Fabrication of Hard–Soft Microfluidic Devices Using Hybrid 3D Printing

Widely accessible, inexpensive, easy-to-use consumer 3D printers, such as desktop stereolithography (SLA) and fused-deposition modeling (FDM) systems are increasingly employed in prototyping and customizing miniaturized fluidic systems for diagnostics and research. However, these 3D printers are gen...

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Autores principales: Ruiz, Carlos, Kadimisetty, Karteek, Yin, Kun, Mauk, Michael G., Zhao, Hui, Liu, Changchun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7345326/
https://www.ncbi.nlm.nih.gov/pubmed/32492980
http://dx.doi.org/10.3390/mi11060567
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author Ruiz, Carlos
Kadimisetty, Karteek
Yin, Kun
Mauk, Michael G.
Zhao, Hui
Liu, Changchun
author_facet Ruiz, Carlos
Kadimisetty, Karteek
Yin, Kun
Mauk, Michael G.
Zhao, Hui
Liu, Changchun
author_sort Ruiz, Carlos
collection PubMed
description Widely accessible, inexpensive, easy-to-use consumer 3D printers, such as desktop stereolithography (SLA) and fused-deposition modeling (FDM) systems are increasingly employed in prototyping and customizing miniaturized fluidic systems for diagnostics and research. However, these 3D printers are generally limited to printing parts made of only one material type, which limits the functionality of the microfluidic devices without additional assembly and bonding steps. Moreover, mating of different materials requires good sealing in such microfluidic devices. Here, we report methods to print hybrid structures comprising a hard, rigid component (clear polymethacrylate polymer) printed by a low-cost SLA printer, and where the first printed part is accurately mated and adhered to a second, soft, flexible component (thermoplastic polyurethane elastomer) printed by an FDM printer. The prescribed mounting and alignment of the first-printed SLA-printed hard component, and its pre-treatment and heating during the second FDM step, can produce leak-free bonds at material interfaces. To demonstrate the utility of such hybrid 3D-printing, we prototype and test three components: i) finger-actuated pump, ii) quick-connect fluid coupler, and iii) nucleic acid amplification test device with screw-type twist sealing for sample introduction.
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spelling pubmed-73453262020-07-09 Fabrication of Hard–Soft Microfluidic Devices Using Hybrid 3D Printing Ruiz, Carlos Kadimisetty, Karteek Yin, Kun Mauk, Michael G. Zhao, Hui Liu, Changchun Micromachines (Basel) Article Widely accessible, inexpensive, easy-to-use consumer 3D printers, such as desktop stereolithography (SLA) and fused-deposition modeling (FDM) systems are increasingly employed in prototyping and customizing miniaturized fluidic systems for diagnostics and research. However, these 3D printers are generally limited to printing parts made of only one material type, which limits the functionality of the microfluidic devices without additional assembly and bonding steps. Moreover, mating of different materials requires good sealing in such microfluidic devices. Here, we report methods to print hybrid structures comprising a hard, rigid component (clear polymethacrylate polymer) printed by a low-cost SLA printer, and where the first printed part is accurately mated and adhered to a second, soft, flexible component (thermoplastic polyurethane elastomer) printed by an FDM printer. The prescribed mounting and alignment of the first-printed SLA-printed hard component, and its pre-treatment and heating during the second FDM step, can produce leak-free bonds at material interfaces. To demonstrate the utility of such hybrid 3D-printing, we prototype and test three components: i) finger-actuated pump, ii) quick-connect fluid coupler, and iii) nucleic acid amplification test device with screw-type twist sealing for sample introduction. MDPI 2020-06-01 /pmc/articles/PMC7345326/ /pubmed/32492980 http://dx.doi.org/10.3390/mi11060567 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Ruiz, Carlos
Kadimisetty, Karteek
Yin, Kun
Mauk, Michael G.
Zhao, Hui
Liu, Changchun
Fabrication of Hard–Soft Microfluidic Devices Using Hybrid 3D Printing
title Fabrication of Hard–Soft Microfluidic Devices Using Hybrid 3D Printing
title_full Fabrication of Hard–Soft Microfluidic Devices Using Hybrid 3D Printing
title_fullStr Fabrication of Hard–Soft Microfluidic Devices Using Hybrid 3D Printing
title_full_unstemmed Fabrication of Hard–Soft Microfluidic Devices Using Hybrid 3D Printing
title_short Fabrication of Hard–Soft Microfluidic Devices Using Hybrid 3D Printing
title_sort fabrication of hard–soft microfluidic devices using hybrid 3d printing
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7345326/
https://www.ncbi.nlm.nih.gov/pubmed/32492980
http://dx.doi.org/10.3390/mi11060567
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