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Breast Abscesses Caused by Anaerobic Microorganisms: Clinical and Microbiological Characteristics

The objectives of this study were to report the antimicrobial susceptibility of 35 clinically significant anaerobic bacteria isolated from breast abscesses between March 2017 and February 2020 in a tertiary hospital in Granada (Spain) and to describe key clinical features of the patients. Species id...

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Autores principales: Cobo, Fernando, Guillot, Vicente, Navarro-Marí, José María
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7345347/
https://www.ncbi.nlm.nih.gov/pubmed/32570867
http://dx.doi.org/10.3390/antibiotics9060341
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author Cobo, Fernando
Guillot, Vicente
Navarro-Marí, José María
author_facet Cobo, Fernando
Guillot, Vicente
Navarro-Marí, José María
author_sort Cobo, Fernando
collection PubMed
description The objectives of this study were to report the antimicrobial susceptibility of 35 clinically significant anaerobic bacteria isolated from breast abscesses between March 2017 and February 2020 in a tertiary hospital in Granada (Spain) and to describe key clinical features of the patients. Species identification was performed mainly by MALDI-TOF MS. Antimicrobial susceptibility tests were carried out against benzylpenicillin, amoxicillin–clavulanic acid, imipenem, moxifloxacin, clindamycin, metronidazole, and piperacillin–tazobactam using the gradient diffusion technique and European Committee on Antimicrobial Susceptibility Testing EUCAST breakpoints (except for moxifloxacin). The most frequent anaerobes were Finegoldia magna (31.4%; n = 11), Actinomyces spp. (17.1%; n = 6), Propionibacterium spp. (17.1%; n = 6), and Prevotella spp. (14.2%; n = 5). Imipenem, amoxicillin–clavulanic acid, and piperacillin–tazobactam were universally active against all genera tested. High overall resistance rates to clindamycin were observed, especially for Gram-positive anaerobic cocci (56.2%) and Gram-positive anaerobic bacilli (38.4%). High resistance rates to metronidazole were also observed for Gram-positive (76.9%) and Gram-negative anaerobic bacilli (50%). High resistance rates to moxifloxacin were found for Gram-negative anaerobic bacilli (50%) and Gram-positive anaerobic cocci (31.2%). No breast abscess cases of Bacteroides spp. were detected. Routine antimicrobial susceptibility testing for anaerobes in breast abscesses may contribute to allow empirical therapies to be selected in accordance with local data on resistant strains.
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spelling pubmed-73453472020-07-09 Breast Abscesses Caused by Anaerobic Microorganisms: Clinical and Microbiological Characteristics Cobo, Fernando Guillot, Vicente Navarro-Marí, José María Antibiotics (Basel) Article The objectives of this study were to report the antimicrobial susceptibility of 35 clinically significant anaerobic bacteria isolated from breast abscesses between March 2017 and February 2020 in a tertiary hospital in Granada (Spain) and to describe key clinical features of the patients. Species identification was performed mainly by MALDI-TOF MS. Antimicrobial susceptibility tests were carried out against benzylpenicillin, amoxicillin–clavulanic acid, imipenem, moxifloxacin, clindamycin, metronidazole, and piperacillin–tazobactam using the gradient diffusion technique and European Committee on Antimicrobial Susceptibility Testing EUCAST breakpoints (except for moxifloxacin). The most frequent anaerobes were Finegoldia magna (31.4%; n = 11), Actinomyces spp. (17.1%; n = 6), Propionibacterium spp. (17.1%; n = 6), and Prevotella spp. (14.2%; n = 5). Imipenem, amoxicillin–clavulanic acid, and piperacillin–tazobactam were universally active against all genera tested. High overall resistance rates to clindamycin were observed, especially for Gram-positive anaerobic cocci (56.2%) and Gram-positive anaerobic bacilli (38.4%). High resistance rates to metronidazole were also observed for Gram-positive (76.9%) and Gram-negative anaerobic bacilli (50%). High resistance rates to moxifloxacin were found for Gram-negative anaerobic bacilli (50%) and Gram-positive anaerobic cocci (31.2%). No breast abscess cases of Bacteroides spp. were detected. Routine antimicrobial susceptibility testing for anaerobes in breast abscesses may contribute to allow empirical therapies to be selected in accordance with local data on resistant strains. MDPI 2020-06-18 /pmc/articles/PMC7345347/ /pubmed/32570867 http://dx.doi.org/10.3390/antibiotics9060341 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Cobo, Fernando
Guillot, Vicente
Navarro-Marí, José María
Breast Abscesses Caused by Anaerobic Microorganisms: Clinical and Microbiological Characteristics
title Breast Abscesses Caused by Anaerobic Microorganisms: Clinical and Microbiological Characteristics
title_full Breast Abscesses Caused by Anaerobic Microorganisms: Clinical and Microbiological Characteristics
title_fullStr Breast Abscesses Caused by Anaerobic Microorganisms: Clinical and Microbiological Characteristics
title_full_unstemmed Breast Abscesses Caused by Anaerobic Microorganisms: Clinical and Microbiological Characteristics
title_short Breast Abscesses Caused by Anaerobic Microorganisms: Clinical and Microbiological Characteristics
title_sort breast abscesses caused by anaerobic microorganisms: clinical and microbiological characteristics
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7345347/
https://www.ncbi.nlm.nih.gov/pubmed/32570867
http://dx.doi.org/10.3390/antibiotics9060341
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