Varespladib Inhibits the Phospholipase A(2) and Coagulopathic Activities of Venom Components from Hemotoxic Snakes

Phospholipase A(2) (PLA(2)) enzymes are important toxins found in many snake venoms, and they can exhibit a variety of toxic activities including causing hemolysis and/or anticoagulation. In this study, the inhibiting effects of the small molecule PLA(2) inhibitor varespladib on snake venom PLA(2)s...

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Detalles Bibliográficos
Autores principales: Xie, Chunfang, Albulescu, Laura-Oana, Still, Kristina B. M., Slagboom, Julien, Zhao, Yumei, Jiang, Zhengjin, Somsen, Govert W., Vonk, Freek J., Casewell, Nicholas R., Kool, Jeroen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7345350/
https://www.ncbi.nlm.nih.gov/pubmed/32560391
http://dx.doi.org/10.3390/biomedicines8060165

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7345350/
https://www.ncbi.nlm.nih.gov/pubmed/32560391
http://dx.doi.org/10.3390/biomedicines8060165

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