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Varespladib Inhibits the Phospholipase A(2) and Coagulopathic Activities of Venom Components from Hemotoxic Snakes

Phospholipase A(2) (PLA(2)) enzymes are important toxins found in many snake venoms, and they can exhibit a variety of toxic activities including causing hemolysis and/or anticoagulation. In this study, the inhibiting effects of the small molecule PLA(2) inhibitor varespladib on snake venom PLA(2)s...

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Detalles Bibliográficos
Autores principales:	Xie, Chunfang, Albulescu, Laura-Oana, Still, Kristina B. M., Slagboom, Julien, Zhao, Yumei, Jiang, Zhengjin, Somsen, Govert W., Vonk, Freek J., Casewell, Nicholas R., Kool, Jeroen
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7345350/ https://www.ncbi.nlm.nih.gov/pubmed/32560391 http://dx.doi.org/10.3390/biomedicines8060165

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