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Stimuli-Responsive Hydrogels for Local Post-Surgical Drug Delivery

Currently, surgical operations, followed by systemic drug delivery, are the prevailing treatment modality for most diseases, including cancers and trauma-based injuries. Although effective to some extent, the side effects of surgery include inflammation, pain, a lower rate of tissue regeneration, di...

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Autores principales: Askari, Esfandyar, Seyfoori, Amir, Amereh, Meitham, Gharaie, Sadaf Samimi, Ghazali, Hanieh Sadat, Ghazali, Zahra Sadat, Khunjush, Bardia, Akbari, Mohsen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7345431/
https://www.ncbi.nlm.nih.gov/pubmed/32397180
http://dx.doi.org/10.3390/gels6020014
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author Askari, Esfandyar
Seyfoori, Amir
Amereh, Meitham
Gharaie, Sadaf Samimi
Ghazali, Hanieh Sadat
Ghazali, Zahra Sadat
Khunjush, Bardia
Akbari, Mohsen
author_facet Askari, Esfandyar
Seyfoori, Amir
Amereh, Meitham
Gharaie, Sadaf Samimi
Ghazali, Hanieh Sadat
Ghazali, Zahra Sadat
Khunjush, Bardia
Akbari, Mohsen
author_sort Askari, Esfandyar
collection PubMed
description Currently, surgical operations, followed by systemic drug delivery, are the prevailing treatment modality for most diseases, including cancers and trauma-based injuries. Although effective to some extent, the side effects of surgery include inflammation, pain, a lower rate of tissue regeneration, disease recurrence, and the non-specific toxicity of chemotherapies, which remain significant clinical challenges. The localized delivery of therapeutics has recently emerged as an alternative to systemic therapy, which not only allows the delivery of higher doses of therapeutic agents to the surgical site, but also enables overcoming post-surgical complications, such as infections, inflammations, and pain. Due to the limitations of the current drug delivery systems, and an increasing clinical need for disease-specific drug release systems, hydrogels have attracted considerable interest, due to their unique properties, including a high capacity for drug loading, as well as a sustained release profile. Hydrogels can be used as local drug performance carriers as a means for diminishing the side effects of current systemic drug delivery methods and are suitable for the majority of surgery-based injuries. This work summarizes recent advances in hydrogel-based drug delivery systems (DDSs), including formulations such as implantable, injectable, and sprayable hydrogels, with a particular emphasis on stimuli-responsive materials. Moreover, clinical applications and future opportunities for this type of post-surgery treatment are also highlighted.
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spelling pubmed-73454312020-07-09 Stimuli-Responsive Hydrogels for Local Post-Surgical Drug Delivery Askari, Esfandyar Seyfoori, Amir Amereh, Meitham Gharaie, Sadaf Samimi Ghazali, Hanieh Sadat Ghazali, Zahra Sadat Khunjush, Bardia Akbari, Mohsen Gels Review Currently, surgical operations, followed by systemic drug delivery, are the prevailing treatment modality for most diseases, including cancers and trauma-based injuries. Although effective to some extent, the side effects of surgery include inflammation, pain, a lower rate of tissue regeneration, disease recurrence, and the non-specific toxicity of chemotherapies, which remain significant clinical challenges. The localized delivery of therapeutics has recently emerged as an alternative to systemic therapy, which not only allows the delivery of higher doses of therapeutic agents to the surgical site, but also enables overcoming post-surgical complications, such as infections, inflammations, and pain. Due to the limitations of the current drug delivery systems, and an increasing clinical need for disease-specific drug release systems, hydrogels have attracted considerable interest, due to their unique properties, including a high capacity for drug loading, as well as a sustained release profile. Hydrogels can be used as local drug performance carriers as a means for diminishing the side effects of current systemic drug delivery methods and are suitable for the majority of surgery-based injuries. This work summarizes recent advances in hydrogel-based drug delivery systems (DDSs), including formulations such as implantable, injectable, and sprayable hydrogels, with a particular emphasis on stimuli-responsive materials. Moreover, clinical applications and future opportunities for this type of post-surgery treatment are also highlighted. MDPI 2020-05-08 /pmc/articles/PMC7345431/ /pubmed/32397180 http://dx.doi.org/10.3390/gels6020014 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Askari, Esfandyar
Seyfoori, Amir
Amereh, Meitham
Gharaie, Sadaf Samimi
Ghazali, Hanieh Sadat
Ghazali, Zahra Sadat
Khunjush, Bardia
Akbari, Mohsen
Stimuli-Responsive Hydrogels for Local Post-Surgical Drug Delivery
title Stimuli-Responsive Hydrogels for Local Post-Surgical Drug Delivery
title_full Stimuli-Responsive Hydrogels for Local Post-Surgical Drug Delivery
title_fullStr Stimuli-Responsive Hydrogels for Local Post-Surgical Drug Delivery
title_full_unstemmed Stimuli-Responsive Hydrogels for Local Post-Surgical Drug Delivery
title_short Stimuli-Responsive Hydrogels for Local Post-Surgical Drug Delivery
title_sort stimuli-responsive hydrogels for local post-surgical drug delivery
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7345431/
https://www.ncbi.nlm.nih.gov/pubmed/32397180
http://dx.doi.org/10.3390/gels6020014
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