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Identification of Plasma Lipidome Changes Associated with Low Dose Space-Type Radiation Exposure in a Murine Model

Long-term exposures to low dose space radiation may have adverse effects on human health during missions in deep space. Conventional dosimetry, monitoring of prodromal symptoms, and peripheral lymphocyte counts are of limited value as biomarkers of organ- and tissue-specific radiation injury, partic...

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Autores principales: Upadhyay, Maarisha, Rajagopal, Meena, Gill, Kirandeep, Li, Yaoxiang, Bansal, Shivani, Sridharan, Vijayalakshmi, Tyburski, John B., Boerma, Marjan, Cheema, Amrita K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7345467/
https://www.ncbi.nlm.nih.gov/pubmed/32560360
http://dx.doi.org/10.3390/metabo10060252
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author Upadhyay, Maarisha
Rajagopal, Meena
Gill, Kirandeep
Li, Yaoxiang
Bansal, Shivani
Sridharan, Vijayalakshmi
Tyburski, John B.
Boerma, Marjan
Cheema, Amrita K.
author_facet Upadhyay, Maarisha
Rajagopal, Meena
Gill, Kirandeep
Li, Yaoxiang
Bansal, Shivani
Sridharan, Vijayalakshmi
Tyburski, John B.
Boerma, Marjan
Cheema, Amrita K.
author_sort Upadhyay, Maarisha
collection PubMed
description Long-term exposures to low dose space radiation may have adverse effects on human health during missions in deep space. Conventional dosimetry, monitoring of prodromal symptoms, and peripheral lymphocyte counts are of limited value as biomarkers of organ- and tissue-specific radiation injury, particularly of injuries that appear weeks or months after radiation exposure. To assess the feasibility of using plasma metabolic and lipidomic profiles as biomarkers of injury from space radiation, we used a mouse model of exposure to low doses of oxygen ions ((16)O) and protons ((1)H). Plasma profiles were compared with those of mice exposed to γ-rays as a reference set. Our results demonstrate major changes in glycerophospholipid metabolism, amino acid metabolism, as well as fatty acid metabolism. We also observed dyslipidemia and lipid peroxidation, suggesting an inflammatory phenotype with possible long-term consequences to overall health upon exposure to low doses of high linear energy transfer (LET) radiation.
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spelling pubmed-73454672020-07-09 Identification of Plasma Lipidome Changes Associated with Low Dose Space-Type Radiation Exposure in a Murine Model Upadhyay, Maarisha Rajagopal, Meena Gill, Kirandeep Li, Yaoxiang Bansal, Shivani Sridharan, Vijayalakshmi Tyburski, John B. Boerma, Marjan Cheema, Amrita K. Metabolites Article Long-term exposures to low dose space radiation may have adverse effects on human health during missions in deep space. Conventional dosimetry, monitoring of prodromal symptoms, and peripheral lymphocyte counts are of limited value as biomarkers of organ- and tissue-specific radiation injury, particularly of injuries that appear weeks or months after radiation exposure. To assess the feasibility of using plasma metabolic and lipidomic profiles as biomarkers of injury from space radiation, we used a mouse model of exposure to low doses of oxygen ions ((16)O) and protons ((1)H). Plasma profiles were compared with those of mice exposed to γ-rays as a reference set. Our results demonstrate major changes in glycerophospholipid metabolism, amino acid metabolism, as well as fatty acid metabolism. We also observed dyslipidemia and lipid peroxidation, suggesting an inflammatory phenotype with possible long-term consequences to overall health upon exposure to low doses of high linear energy transfer (LET) radiation. MDPI 2020-06-17 /pmc/articles/PMC7345467/ /pubmed/32560360 http://dx.doi.org/10.3390/metabo10060252 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Upadhyay, Maarisha
Rajagopal, Meena
Gill, Kirandeep
Li, Yaoxiang
Bansal, Shivani
Sridharan, Vijayalakshmi
Tyburski, John B.
Boerma, Marjan
Cheema, Amrita K.
Identification of Plasma Lipidome Changes Associated with Low Dose Space-Type Radiation Exposure in a Murine Model
title Identification of Plasma Lipidome Changes Associated with Low Dose Space-Type Radiation Exposure in a Murine Model
title_full Identification of Plasma Lipidome Changes Associated with Low Dose Space-Type Radiation Exposure in a Murine Model
title_fullStr Identification of Plasma Lipidome Changes Associated with Low Dose Space-Type Radiation Exposure in a Murine Model
title_full_unstemmed Identification of Plasma Lipidome Changes Associated with Low Dose Space-Type Radiation Exposure in a Murine Model
title_short Identification of Plasma Lipidome Changes Associated with Low Dose Space-Type Radiation Exposure in a Murine Model
title_sort identification of plasma lipidome changes associated with low dose space-type radiation exposure in a murine model
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7345467/
https://www.ncbi.nlm.nih.gov/pubmed/32560360
http://dx.doi.org/10.3390/metabo10060252
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