Hydralazine Sensitizes to the Antifibrotic Effect of 5-Aza-2′-deoxycytidine in Hepatic Stellate Cells

Background: Hepatic stellate cell (HSC) activation is essential for the development of liver fibrosis. Epigenetic machinery, such as DNA methylation, is largely involved in the regulation of gene expression during HSC activation. Although the pharmacological DNA demethylation of HSC using 5-aza-2′-d...

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Detalles Bibliográficos
Autores principales: Asada, Kiyoshi, Kaji, Kosuke, Sato, Shinya, Seki, Kenichiro, Shimozato, Naotaka, Kawaratani, Hideto, Takaya, Hiroaki, Sawada, Yasuhiko, Nakanishi, Keisuke, Furukawa, Masanori, Kitade, Mitsuteru, Moriya, Kei, Namisaki, Tadashi, Noguchi, Ryuichi, Akahane, Takemi, Yoshiji, Hitoshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7345531/
https://www.ncbi.nlm.nih.gov/pubmed/32503264
http://dx.doi.org/10.3390/biology9060117

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