Synthesis and Biological Evaluation of Diversified Hamigeran B Analogs as Neuroinflammatory Inhibitors and Neurite Outgrowth Stimulators

We describe the efficient synthesis of a series of new simplified hamigeran B and 1-hydroxy-9-epi-hamigeran B norditerpenoid analogs (23 new members in all), structurally related to cyathane diterpenoid scaffold, and their anti-neuroinflammatory and neurite outgrowth-stimulating (neurotrophic) activ...

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Detalles Bibliográficos
Autores principales: Li, Ruo-Xin, Han, Rui, Wu, Guo-Jie, Han, Fu-She, Gao, Jin-Ming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7345552/
https://www.ncbi.nlm.nih.gov/pubmed/32545418
http://dx.doi.org/10.3390/md18060306

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7345552/
https://www.ncbi.nlm.nih.gov/pubmed/32545418
http://dx.doi.org/10.3390/md18060306

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