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Rifabutin Use in Staphylococcus Biofilm Infections: A Case Series

This is a case series of 10 patients who had staphylococcal biofilm infections that were treated with adjuvant rifabutin therapy instead of rifampin therapy. In these cases, rifampin was contraindicated secondary to drug–drug interactions with the patients’ chronic medications. Rifabutin therapy was...

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Autores principales: Doub, James B., Heil, Emily L., Ntem-Mensah, Afua, Neeley, Renaldo, Ching, Patrick R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7345564/
https://www.ncbi.nlm.nih.gov/pubmed/32545793
http://dx.doi.org/10.3390/antibiotics9060326
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author Doub, James B.
Heil, Emily L.
Ntem-Mensah, Afua
Neeley, Renaldo
Ching, Patrick R.
author_facet Doub, James B.
Heil, Emily L.
Ntem-Mensah, Afua
Neeley, Renaldo
Ching, Patrick R.
author_sort Doub, James B.
collection PubMed
description This is a case series of 10 patients who had staphylococcal biofilm infections that were treated with adjuvant rifabutin therapy instead of rifampin therapy. In these cases, rifampin was contraindicated secondary to drug–drug interactions with the patients’ chronic medications. Rifabutin therapy was well tolerated with no side effects. As well, no patients had recurrence of their staphylococcal infections. This case series shows that rifabutin can be a beneficial adjuvant therapy in Staphylococcus biofilm infections when drug–drug interactions limit the use of rifampin.
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spelling pubmed-73455642020-07-09 Rifabutin Use in Staphylococcus Biofilm Infections: A Case Series Doub, James B. Heil, Emily L. Ntem-Mensah, Afua Neeley, Renaldo Ching, Patrick R. Antibiotics (Basel) Case Report This is a case series of 10 patients who had staphylococcal biofilm infections that were treated with adjuvant rifabutin therapy instead of rifampin therapy. In these cases, rifampin was contraindicated secondary to drug–drug interactions with the patients’ chronic medications. Rifabutin therapy was well tolerated with no side effects. As well, no patients had recurrence of their staphylococcal infections. This case series shows that rifabutin can be a beneficial adjuvant therapy in Staphylococcus biofilm infections when drug–drug interactions limit the use of rifampin. MDPI 2020-06-13 /pmc/articles/PMC7345564/ /pubmed/32545793 http://dx.doi.org/10.3390/antibiotics9060326 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Case Report
Doub, James B.
Heil, Emily L.
Ntem-Mensah, Afua
Neeley, Renaldo
Ching, Patrick R.
Rifabutin Use in Staphylococcus Biofilm Infections: A Case Series
title Rifabutin Use in Staphylococcus Biofilm Infections: A Case Series
title_full Rifabutin Use in Staphylococcus Biofilm Infections: A Case Series
title_fullStr Rifabutin Use in Staphylococcus Biofilm Infections: A Case Series
title_full_unstemmed Rifabutin Use in Staphylococcus Biofilm Infections: A Case Series
title_short Rifabutin Use in Staphylococcus Biofilm Infections: A Case Series
title_sort rifabutin use in staphylococcus biofilm infections: a case series
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7345564/
https://www.ncbi.nlm.nih.gov/pubmed/32545793
http://dx.doi.org/10.3390/antibiotics9060326
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