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Discussing the Score of Cardioembolic Ischemic Stroke in Chagas Disease

Chagas disease is an important infection in Latin America but it is also reported in non-endemic countries all over the world. Around 30% of infected patients develop chronic Chagas cardiopathy, which is responsible for most poor outcomes, mainly heart failure, arrhythmias and thromboembolic events....

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Detalles Bibliográficos
Autores principales: Mendes, Fernanda de Souza Nogueira Sardinha, Mediano, Mauro Felippe Felix, Silva, Rudson Santos, Xavier, Sergio Salles, do Brasil, Pedro Emmanuel Alvarenga Americano, Saraiva, Roberto Magalhães, Hasslocher-Moreno, Alejandro Marcel, de Sousa, Andrea Silvestre
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7345975/
https://www.ncbi.nlm.nih.gov/pubmed/32466425
http://dx.doi.org/10.3390/tropicalmed5020082
Descripción
Sumario:Chagas disease is an important infection in Latin America but it is also reported in non-endemic countries all over the world. Around 30% of infected patients develop chronic Chagas cardiopathy, which is responsible for most poor outcomes, mainly heart failure, arrhythmias and thromboembolic events. Of all thromboembolic events, stroke is the most feared, due to the high probability of evolution to death or disability. Despite its importance, the actual incidence of cardioembolic ischemic stroke in Chagas disease is not completely known. The Instituto de Pesquisa Evandro Chagas/Fundação Oswaldo Cruz (IPEC-FIOCRUZ) score aims to propose prophylaxis strategies against cardioembolic ischemic stroke in Chagas disease based on clinical risk–benefit. To date, the IPEC-FIOCRUZ score is considered the best tool to identify patients for stroke prophylaxis in Chagas disease according the Latin American guideline and Brazilian consensus. It can prevent many cardioembolic strokes that would not be predicted, by applying the current recommendations to other cardiopathies. However, the IPEC-FIOCRUZ score still requires external validation to be used in different Chagas disease populations with an appropriate study design.