Keap1-Nrf2 signaling activation by Bardoxolone-methyl ameliorates high glucose-induced oxidative injury in human umbilical vein endothelial cells

In cultured human umbilical vein endothelial cells (HUVECs) high glucose (HG) stimulation will lead to significant cell death. Bardoxolone-methyl (BARD) is a NF-E2 p45-related factor 2 (Nrf2) agonist. In this study we show that BARD, at only nM concentrations, activated Nrf2 signaling in HUVECs. BAR...

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Detalles Bibliográficos
Autores principales: Yang, Jing-Lei, Sun, Meng-Yue, Yuan, Qi, Tang, Shan, Dong, Mei-Juan, Zhang, Ri-Dong, Liu, Yuan-Yuan, Mao, Li
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals 2020
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7346051/
https://www.ncbi.nlm.nih.gov/pubmed/32484788
http://dx.doi.org/10.18632/aging.103263

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7346051/
https://www.ncbi.nlm.nih.gov/pubmed/32484788
http://dx.doi.org/10.18632/aging.103263

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