Epigenome-wide gene–age interaction analysis reveals reversed effects of PRODH DNA methylation on survival between young and elderly early-stage NSCLC patients

DNA methylation changes during aging, but it remains unclear whether the effect of DNA methylation on lung cancer survival varies with age. Such an effect could decrease prediction accuracy and treatment efficacy. We performed a methylation–age interaction analysis using 1,230 early-stage lung adeno...

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Detalles Bibliográficos
Autores principales: Chen, Chao, Wei, Yongyue, Wei, Liangmin, Chen, Jiajin, Chen, Xin, Dong, Xuesi, He, Jieyu, Lin, Lijuan, Zhu, Ying, Huang, Hui, You, Dongfang, Lai, Linjing, Shen, Sipeng, Duan, Weiwei, Su, Li, Shafer, Andrea, Fleischer, Thomas, Bjaanæs, Maria Moksnes, Karlsson, Anna, Planck, Maria, Wang, Rui, Staaf, Johan, Helland, Åslaug, Esteller, Manel, Zhang, Ruyang, Chen, Feng, Christiani, David C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals 2020
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7346054/
https://www.ncbi.nlm.nih.gov/pubmed/32511103
http://dx.doi.org/10.18632/aging.103284

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