LINC01419 facilitates hepatocellular carcinoma growth and metastasis through targeting EZH2-regulated RECK

Long non-coding RNAs (lncRNAs) have been reported to play significant roles in human tumorigenesis, for example, in hepatocellular carcinoma (HCC). This study explored the role of LINC01419, a new lncRNA, in HCC. In vitro study revealed that LINC01419 promotes growth and migration of HCC cells. Gene...

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Detalles Bibliográficos
Autores principales: Zhang, Gong, Chen, Ximin, Ma, Lei, Ding, Rui, Zhao, Lihong, Ma, Feng, Deng, Xubin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals 2020
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7346057/
https://www.ncbi.nlm.nih.gov/pubmed/32522890
http://dx.doi.org/10.18632/aging.103321
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author Zhang, Gong
Chen, Ximin
Ma, Lei
Ding, Rui
Zhao, Lihong
Ma, Feng
Deng, Xubin
author_facet Zhang, Gong
Chen, Ximin
Ma, Lei
Ding, Rui
Zhao, Lihong
Ma, Feng
Deng, Xubin
author_sort Zhang, Gong
collection PubMed
description Long non-coding RNAs (lncRNAs) have been reported to play significant roles in human tumorigenesis, for example, in hepatocellular carcinoma (HCC). This study explored the role of LINC01419, a new lncRNA, in HCC. In vitro study revealed that LINC01419 promotes growth and migration of HCC cells. Genes that affected cell proliferation and cell migration were identified using RNA-sequence. Subsequently, it was confirmed that LINC01419 binds to EZH2, leading to histone methylation of the RECK promoter. Interaction between LINC01419 and FUS stabilized EZH2 mRNA thereby enhancing EZH2 expression. Conclusively, the results of this study confirm that LINC01419 may serve as a potential target for HCC diagnosis and treatment.
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spelling pubmed-73460572020-07-15 LINC01419 facilitates hepatocellular carcinoma growth and metastasis through targeting EZH2-regulated RECK Zhang, Gong Chen, Ximin Ma, Lei Ding, Rui Zhao, Lihong Ma, Feng Deng, Xubin Aging (Albany NY) Research Paper Long non-coding RNAs (lncRNAs) have been reported to play significant roles in human tumorigenesis, for example, in hepatocellular carcinoma (HCC). This study explored the role of LINC01419, a new lncRNA, in HCC. In vitro study revealed that LINC01419 promotes growth and migration of HCC cells. Genes that affected cell proliferation and cell migration were identified using RNA-sequence. Subsequently, it was confirmed that LINC01419 binds to EZH2, leading to histone methylation of the RECK promoter. Interaction between LINC01419 and FUS stabilized EZH2 mRNA thereby enhancing EZH2 expression. Conclusively, the results of this study confirm that LINC01419 may serve as a potential target for HCC diagnosis and treatment. Impact Journals 2020-06-10 /pmc/articles/PMC7346057/ /pubmed/32522890 http://dx.doi.org/10.18632/aging.103321 Text en Copyright © 2020 Zhang et al. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Paper
Zhang, Gong
Chen, Ximin
Ma, Lei
Ding, Rui
Zhao, Lihong
Ma, Feng
Deng, Xubin
LINC01419 facilitates hepatocellular carcinoma growth and metastasis through targeting EZH2-regulated RECK
title LINC01419 facilitates hepatocellular carcinoma growth and metastasis through targeting EZH2-regulated RECK
title_full LINC01419 facilitates hepatocellular carcinoma growth and metastasis through targeting EZH2-regulated RECK
title_fullStr LINC01419 facilitates hepatocellular carcinoma growth and metastasis through targeting EZH2-regulated RECK
title_full_unstemmed LINC01419 facilitates hepatocellular carcinoma growth and metastasis through targeting EZH2-regulated RECK
title_short LINC01419 facilitates hepatocellular carcinoma growth and metastasis through targeting EZH2-regulated RECK
title_sort linc01419 facilitates hepatocellular carcinoma growth and metastasis through targeting ezh2-regulated reck
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7346057/
https://www.ncbi.nlm.nih.gov/pubmed/32522890
http://dx.doi.org/10.18632/aging.103321
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