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Resveratrol promotes osteogenesis and alleviates osteoporosis by inhibiting p53
Although osteoporosis is one of the most common chronic age-related diseases, there is currently no gold standard for treatment. Evidence suggests resveratrol, a natural polyphenolic compound, may be helpful in the treatment of osteoporosis and other diseases. However, the molecular mechanisms under...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Impact Journals
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7346062/ https://www.ncbi.nlm.nih.gov/pubmed/32459661 http://dx.doi.org/10.18632/aging.103262 |
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author | Yu, Tao Wang, Zaiyan You, Xiaomeng Zhou, Haichao He, Wenbao Li, Bing Xia, Jiang Zhu, Hui Zhao, Youguang Yu, Guangrong Xiong, Yuan Yang, Yunfeng |
author_facet | Yu, Tao Wang, Zaiyan You, Xiaomeng Zhou, Haichao He, Wenbao Li, Bing Xia, Jiang Zhu, Hui Zhao, Youguang Yu, Guangrong Xiong, Yuan Yang, Yunfeng |
author_sort | Yu, Tao |
collection | PubMed |
description | Although osteoporosis is one of the most common chronic age-related diseases, there is currently no gold standard for treatment. Evidence suggests resveratrol, a natural polyphenolic compound, may be helpful in the treatment of osteoporosis and other diseases. However, the molecular mechanisms underlying the anti-osteoporotic effects of resveratrol remain largely unknown. In the present study, KEGG pathway enrichment analysis of resveratrol-targeted genes identified 33 associated pathways, 12 of which were also involved in osteoporosis. In particular, the MDM2/p53 signaling pathway was identified as a potential key pathway among the shared pathways. In vitro experiments indicated that MDM2-mediated p53 degradation induced osteoblast differentiation, and resveratrol could partially reverse p53-dependent inhibition of osteogenic differentiation. These findings suggest resveratrol may alleviate osteoporosis at least in part by modulating the MDM2/p53 signaling pathway. |
format | Online Article Text |
id | pubmed-7346062 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Impact Journals |
record_format | MEDLINE/PubMed |
spelling | pubmed-73460622020-07-15 Resveratrol promotes osteogenesis and alleviates osteoporosis by inhibiting p53 Yu, Tao Wang, Zaiyan You, Xiaomeng Zhou, Haichao He, Wenbao Li, Bing Xia, Jiang Zhu, Hui Zhao, Youguang Yu, Guangrong Xiong, Yuan Yang, Yunfeng Aging (Albany NY) Research Paper Although osteoporosis is one of the most common chronic age-related diseases, there is currently no gold standard for treatment. Evidence suggests resveratrol, a natural polyphenolic compound, may be helpful in the treatment of osteoporosis and other diseases. However, the molecular mechanisms underlying the anti-osteoporotic effects of resveratrol remain largely unknown. In the present study, KEGG pathway enrichment analysis of resveratrol-targeted genes identified 33 associated pathways, 12 of which were also involved in osteoporosis. In particular, the MDM2/p53 signaling pathway was identified as a potential key pathway among the shared pathways. In vitro experiments indicated that MDM2-mediated p53 degradation induced osteoblast differentiation, and resveratrol could partially reverse p53-dependent inhibition of osteogenic differentiation. These findings suggest resveratrol may alleviate osteoporosis at least in part by modulating the MDM2/p53 signaling pathway. Impact Journals 2020-05-27 /pmc/articles/PMC7346062/ /pubmed/32459661 http://dx.doi.org/10.18632/aging.103262 Text en Copyright © 2020 Yu et al. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Paper Yu, Tao Wang, Zaiyan You, Xiaomeng Zhou, Haichao He, Wenbao Li, Bing Xia, Jiang Zhu, Hui Zhao, Youguang Yu, Guangrong Xiong, Yuan Yang, Yunfeng Resveratrol promotes osteogenesis and alleviates osteoporosis by inhibiting p53 |
title | Resveratrol promotes osteogenesis and alleviates osteoporosis by inhibiting p53 |
title_full | Resveratrol promotes osteogenesis and alleviates osteoporosis by inhibiting p53 |
title_fullStr | Resveratrol promotes osteogenesis and alleviates osteoporosis by inhibiting p53 |
title_full_unstemmed | Resveratrol promotes osteogenesis and alleviates osteoporosis by inhibiting p53 |
title_short | Resveratrol promotes osteogenesis and alleviates osteoporosis by inhibiting p53 |
title_sort | resveratrol promotes osteogenesis and alleviates osteoporosis by inhibiting p53 |
topic | Research Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7346062/ https://www.ncbi.nlm.nih.gov/pubmed/32459661 http://dx.doi.org/10.18632/aging.103262 |
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