The Impact of Acetyl-CoA and Aspartate Shortages on the N-Acetylaspartate Level in Different Models of Cholinergic Neurons

N-acetylaspartate is produced by neuronal aspartate N-acetyltransferase (NAT8L) from acetyl-CoA and aspartate. In cholinergic neurons, acetyl-CoA is also utilized in the mitochondrial tricarboxylic acid cycle and in acetylcholine production pathways. While aspartate has to be shared with the malate–...

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Detalles Bibliográficos
Autores principales: Zyśk, Marlena, Sakowicz-Burkiewicz, Monika, Pikul, Piotr, Kowalski, Robert, Michno, Anna, Pawełczyk, Tadeusz
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7346116/
https://www.ncbi.nlm.nih.gov/pubmed/32545833
http://dx.doi.org/10.3390/antiox9060522

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7346116/
https://www.ncbi.nlm.nih.gov/pubmed/32545833
http://dx.doi.org/10.3390/antiox9060522

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