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Polyphenols as Possible Agents for Pancreatic Diseases

Pancreatic cancer (PC) is very aggressive and it is estimated that it kills nearly 50% of patients within the first six months. The lack of symptoms specific to this disease prevents early diagnosis and treatment. Today, gemcitabine alone or in combination with other cytostatic agents such as cispla...

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Autores principales: Gašić, Uroš, Ćirić, Ivanka, Pejčić, Tomislav, Radenković, Dejan, Djordjević, Vladimir, Radulović, Siniša, Tešić, Živoslav
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7346180/
https://www.ncbi.nlm.nih.gov/pubmed/32585831
http://dx.doi.org/10.3390/antiox9060547
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author Gašić, Uroš
Ćirić, Ivanka
Pejčić, Tomislav
Radenković, Dejan
Djordjević, Vladimir
Radulović, Siniša
Tešić, Živoslav
author_facet Gašić, Uroš
Ćirić, Ivanka
Pejčić, Tomislav
Radenković, Dejan
Djordjević, Vladimir
Radulović, Siniša
Tešić, Živoslav
author_sort Gašić, Uroš
collection PubMed
description Pancreatic cancer (PC) is very aggressive and it is estimated that it kills nearly 50% of patients within the first six months. The lack of symptoms specific to this disease prevents early diagnosis and treatment. Today, gemcitabine alone or in combination with other cytostatic agents such as cisplatin (Cis), 5-fluorouracil (5-FU), irinotecan, capecitabine, or oxaliplatin (Oxa) is used in conventional therapy. Outgoing literature provides data on the use of polyphenols, biologically active compounds, in the treatment of pancreatic cancer and the prevention of acute pancreatitis. Therefore, the first part of this review gives a brief overview of the state of pancreatic disease as well as the procedures for its treatment. The second part provides a detailed overview of the research regarding the anticancer effects of both pure polyphenols and their plant extracts. The results regarding the antiproliferative, antimetastatic, as well as inhibitory effects of polyphenols against PC cell lines as well as the prevention of acute pancreatitis are presented in detail. Finally, particular emphasis is given to the polyphenolic profiles of apples, berries, cherries, sour cherries, and grapes, given the fact that these fruits are rich in polyphenols and anthocyanins. Polyphenolic profiles, the content of individual polyphenols, and their relationships are discussed. Based on this, significant data can be obtained regarding the amount of fruit that should be consumed daily to achieve a therapeutic effect.
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spelling pubmed-73461802020-07-14 Polyphenols as Possible Agents for Pancreatic Diseases Gašić, Uroš Ćirić, Ivanka Pejčić, Tomislav Radenković, Dejan Djordjević, Vladimir Radulović, Siniša Tešić, Živoslav Antioxidants (Basel) Review Pancreatic cancer (PC) is very aggressive and it is estimated that it kills nearly 50% of patients within the first six months. The lack of symptoms specific to this disease prevents early diagnosis and treatment. Today, gemcitabine alone or in combination with other cytostatic agents such as cisplatin (Cis), 5-fluorouracil (5-FU), irinotecan, capecitabine, or oxaliplatin (Oxa) is used in conventional therapy. Outgoing literature provides data on the use of polyphenols, biologically active compounds, in the treatment of pancreatic cancer and the prevention of acute pancreatitis. Therefore, the first part of this review gives a brief overview of the state of pancreatic disease as well as the procedures for its treatment. The second part provides a detailed overview of the research regarding the anticancer effects of both pure polyphenols and their plant extracts. The results regarding the antiproliferative, antimetastatic, as well as inhibitory effects of polyphenols against PC cell lines as well as the prevention of acute pancreatitis are presented in detail. Finally, particular emphasis is given to the polyphenolic profiles of apples, berries, cherries, sour cherries, and grapes, given the fact that these fruits are rich in polyphenols and anthocyanins. Polyphenolic profiles, the content of individual polyphenols, and their relationships are discussed. Based on this, significant data can be obtained regarding the amount of fruit that should be consumed daily to achieve a therapeutic effect. MDPI 2020-06-23 /pmc/articles/PMC7346180/ /pubmed/32585831 http://dx.doi.org/10.3390/antiox9060547 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Gašić, Uroš
Ćirić, Ivanka
Pejčić, Tomislav
Radenković, Dejan
Djordjević, Vladimir
Radulović, Siniša
Tešić, Živoslav
Polyphenols as Possible Agents for Pancreatic Diseases
title Polyphenols as Possible Agents for Pancreatic Diseases
title_full Polyphenols as Possible Agents for Pancreatic Diseases
title_fullStr Polyphenols as Possible Agents for Pancreatic Diseases
title_full_unstemmed Polyphenols as Possible Agents for Pancreatic Diseases
title_short Polyphenols as Possible Agents for Pancreatic Diseases
title_sort polyphenols as possible agents for pancreatic diseases
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7346180/
https://www.ncbi.nlm.nih.gov/pubmed/32585831
http://dx.doi.org/10.3390/antiox9060547
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