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Terpenoids as Potential Geroprotectors
Terpenes and terpenoids are the largest groups of plant secondary metabolites. However, unlike polyphenols, they are rarely associated with geroprotective properties. Here we evaluated the conformity of the biological effects of terpenoids with the criteria of geroprotectors, including primary crite...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7346221/ https://www.ncbi.nlm.nih.gov/pubmed/32560451 http://dx.doi.org/10.3390/antiox9060529 |
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author | Proshkina, Ekaterina Plyusnin, Sergey Babak, Tatyana Lashmanova, Ekaterina Maganova, Faniya Koval, Liubov Platonova, Elena Shaposhnikov, Mikhail Moskalev, Alexey |
author_facet | Proshkina, Ekaterina Plyusnin, Sergey Babak, Tatyana Lashmanova, Ekaterina Maganova, Faniya Koval, Liubov Platonova, Elena Shaposhnikov, Mikhail Moskalev, Alexey |
author_sort | Proshkina, Ekaterina |
collection | PubMed |
description | Terpenes and terpenoids are the largest groups of plant secondary metabolites. However, unlike polyphenols, they are rarely associated with geroprotective properties. Here we evaluated the conformity of the biological effects of terpenoids with the criteria of geroprotectors, including primary criteria (lifespan-extending effects in model organisms, improvement of aging biomarkers, low toxicity, minimal adverse effects, improvement of the quality of life) and secondary criteria (evolutionarily conserved mechanisms of action, reproducibility of the effects on different models, prevention of age-associated diseases, increasing of stress-resistance). The number of substances that demonstrate the greatest compliance with both primary and secondary criteria of geroprotectors were found among different classes of terpenoids. Thus, terpenoids are an underestimated source of potential geroprotectors that can effectively influence the mechanisms of aging and age-related diseases. |
format | Online Article Text |
id | pubmed-7346221 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-73462212020-07-20 Terpenoids as Potential Geroprotectors Proshkina, Ekaterina Plyusnin, Sergey Babak, Tatyana Lashmanova, Ekaterina Maganova, Faniya Koval, Liubov Platonova, Elena Shaposhnikov, Mikhail Moskalev, Alexey Antioxidants (Basel) Review Terpenes and terpenoids are the largest groups of plant secondary metabolites. However, unlike polyphenols, they are rarely associated with geroprotective properties. Here we evaluated the conformity of the biological effects of terpenoids with the criteria of geroprotectors, including primary criteria (lifespan-extending effects in model organisms, improvement of aging biomarkers, low toxicity, minimal adverse effects, improvement of the quality of life) and secondary criteria (evolutionarily conserved mechanisms of action, reproducibility of the effects on different models, prevention of age-associated diseases, increasing of stress-resistance). The number of substances that demonstrate the greatest compliance with both primary and secondary criteria of geroprotectors were found among different classes of terpenoids. Thus, terpenoids are an underestimated source of potential geroprotectors that can effectively influence the mechanisms of aging and age-related diseases. MDPI 2020-06-17 /pmc/articles/PMC7346221/ /pubmed/32560451 http://dx.doi.org/10.3390/antiox9060529 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Proshkina, Ekaterina Plyusnin, Sergey Babak, Tatyana Lashmanova, Ekaterina Maganova, Faniya Koval, Liubov Platonova, Elena Shaposhnikov, Mikhail Moskalev, Alexey Terpenoids as Potential Geroprotectors |
title | Terpenoids as Potential Geroprotectors |
title_full | Terpenoids as Potential Geroprotectors |
title_fullStr | Terpenoids as Potential Geroprotectors |
title_full_unstemmed | Terpenoids as Potential Geroprotectors |
title_short | Terpenoids as Potential Geroprotectors |
title_sort | terpenoids as potential geroprotectors |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7346221/ https://www.ncbi.nlm.nih.gov/pubmed/32560451 http://dx.doi.org/10.3390/antiox9060529 |
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