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Terpenoids as Potential Geroprotectors

Terpenes and terpenoids are the largest groups of plant secondary metabolites. However, unlike polyphenols, they are rarely associated with geroprotective properties. Here we evaluated the conformity of the biological effects of terpenoids with the criteria of geroprotectors, including primary crite...

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Autores principales: Proshkina, Ekaterina, Plyusnin, Sergey, Babak, Tatyana, Lashmanova, Ekaterina, Maganova, Faniya, Koval, Liubov, Platonova, Elena, Shaposhnikov, Mikhail, Moskalev, Alexey
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7346221/
https://www.ncbi.nlm.nih.gov/pubmed/32560451
http://dx.doi.org/10.3390/antiox9060529
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author Proshkina, Ekaterina
Plyusnin, Sergey
Babak, Tatyana
Lashmanova, Ekaterina
Maganova, Faniya
Koval, Liubov
Platonova, Elena
Shaposhnikov, Mikhail
Moskalev, Alexey
author_facet Proshkina, Ekaterina
Plyusnin, Sergey
Babak, Tatyana
Lashmanova, Ekaterina
Maganova, Faniya
Koval, Liubov
Platonova, Elena
Shaposhnikov, Mikhail
Moskalev, Alexey
author_sort Proshkina, Ekaterina
collection PubMed
description Terpenes and terpenoids are the largest groups of plant secondary metabolites. However, unlike polyphenols, they are rarely associated with geroprotective properties. Here we evaluated the conformity of the biological effects of terpenoids with the criteria of geroprotectors, including primary criteria (lifespan-extending effects in model organisms, improvement of aging biomarkers, low toxicity, minimal adverse effects, improvement of the quality of life) and secondary criteria (evolutionarily conserved mechanisms of action, reproducibility of the effects on different models, prevention of age-associated diseases, increasing of stress-resistance). The number of substances that demonstrate the greatest compliance with both primary and secondary criteria of geroprotectors were found among different classes of terpenoids. Thus, terpenoids are an underestimated source of potential geroprotectors that can effectively influence the mechanisms of aging and age-related diseases.
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spelling pubmed-73462212020-07-20 Terpenoids as Potential Geroprotectors Proshkina, Ekaterina Plyusnin, Sergey Babak, Tatyana Lashmanova, Ekaterina Maganova, Faniya Koval, Liubov Platonova, Elena Shaposhnikov, Mikhail Moskalev, Alexey Antioxidants (Basel) Review Terpenes and terpenoids are the largest groups of plant secondary metabolites. However, unlike polyphenols, they are rarely associated with geroprotective properties. Here we evaluated the conformity of the biological effects of terpenoids with the criteria of geroprotectors, including primary criteria (lifespan-extending effects in model organisms, improvement of aging biomarkers, low toxicity, minimal adverse effects, improvement of the quality of life) and secondary criteria (evolutionarily conserved mechanisms of action, reproducibility of the effects on different models, prevention of age-associated diseases, increasing of stress-resistance). The number of substances that demonstrate the greatest compliance with both primary and secondary criteria of geroprotectors were found among different classes of terpenoids. Thus, terpenoids are an underestimated source of potential geroprotectors that can effectively influence the mechanisms of aging and age-related diseases. MDPI 2020-06-17 /pmc/articles/PMC7346221/ /pubmed/32560451 http://dx.doi.org/10.3390/antiox9060529 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Proshkina, Ekaterina
Plyusnin, Sergey
Babak, Tatyana
Lashmanova, Ekaterina
Maganova, Faniya
Koval, Liubov
Platonova, Elena
Shaposhnikov, Mikhail
Moskalev, Alexey
Terpenoids as Potential Geroprotectors
title Terpenoids as Potential Geroprotectors
title_full Terpenoids as Potential Geroprotectors
title_fullStr Terpenoids as Potential Geroprotectors
title_full_unstemmed Terpenoids as Potential Geroprotectors
title_short Terpenoids as Potential Geroprotectors
title_sort terpenoids as potential geroprotectors
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7346221/
https://www.ncbi.nlm.nih.gov/pubmed/32560451
http://dx.doi.org/10.3390/antiox9060529
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