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Genetic determinants of obesity heterogeneity in type II diabetes

BACKGROUND: Although obesity is considered as the main cause of Type II diabetes (T2DM), non-obese individuals may still develop T2DM and obese individuals may not. METHOD: The mRNA expression of PI3K/AKT axis from 100 non-obese and obese participants with insulin sensitivity and insulin resistance...

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Autores principales: Hosseini Khorami, Somayeh Alsadat, Mutalib, Mohd Sokhini Abd, Feili Shiraz, Mohammad, Abdullah, Joseph Anthony, Rejali, Zulida, Ali, Razana Mohd, Khaza’ai, Huzwah
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7346329/
https://www.ncbi.nlm.nih.gov/pubmed/32670384
http://dx.doi.org/10.1186/s12986-020-00476-6
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author Hosseini Khorami, Somayeh Alsadat
Mutalib, Mohd Sokhini Abd
Feili Shiraz, Mohammad
Abdullah, Joseph Anthony
Rejali, Zulida
Ali, Razana Mohd
Khaza’ai, Huzwah
author_facet Hosseini Khorami, Somayeh Alsadat
Mutalib, Mohd Sokhini Abd
Feili Shiraz, Mohammad
Abdullah, Joseph Anthony
Rejali, Zulida
Ali, Razana Mohd
Khaza’ai, Huzwah
author_sort Hosseini Khorami, Somayeh Alsadat
collection PubMed
description BACKGROUND: Although obesity is considered as the main cause of Type II diabetes (T2DM), non-obese individuals may still develop T2DM and obese individuals may not. METHOD: The mRNA expression of PI3K/AKT axis from 100 non-obese and obese participants with insulin sensitivity and insulin resistance states were compared in this study toward the understanding of obesity heterogeneity molecular mechanism. RESULT: In present study, there was no statistically significant difference in gene expression levels of IRS1 and PTEN between groups, whereas PI3K, AKT2 and GLUT4 genes were expressed at a lower level in obese diabetic group compared to other groups and were statistically significant. PDK1 gene was expressed at a higher level in non-obese diabetic group compared to obese diabetic and non-obese non-diabetics groups. No statistically significant difference was identified in gene expression pattern of PI3K/AKT pathway between obese non-diabetics and non-obese non-diabetics. CONCLUSION: The components of PI3K/AKT pathway which is related to the fasting state, showed reduced expression in obese diabetic group due to the chronic over-nutrition which may induced insensitivity and reduced gene expression. The pathogenesis of insulin resistance in the absence of obesity in non-obese diabetic group could be due to disturbance in another pathway related to the non-fasting state like gluconeogenesis. Therefore, the molecular mechanism of insulin signalling in non-obese diabetic individuals is different from obese diabetics which more investigations are required to study insulin signalling pathways in greater depth, in order to assess nutritional factors, contribute to insulin resistance in obese diabetic and non-obese diabetic individuals.
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spelling pubmed-73463292020-07-14 Genetic determinants of obesity heterogeneity in type II diabetes Hosseini Khorami, Somayeh Alsadat Mutalib, Mohd Sokhini Abd Feili Shiraz, Mohammad Abdullah, Joseph Anthony Rejali, Zulida Ali, Razana Mohd Khaza’ai, Huzwah Nutr Metab (Lond) Research BACKGROUND: Although obesity is considered as the main cause of Type II diabetes (T2DM), non-obese individuals may still develop T2DM and obese individuals may not. METHOD: The mRNA expression of PI3K/AKT axis from 100 non-obese and obese participants with insulin sensitivity and insulin resistance states were compared in this study toward the understanding of obesity heterogeneity molecular mechanism. RESULT: In present study, there was no statistically significant difference in gene expression levels of IRS1 and PTEN between groups, whereas PI3K, AKT2 and GLUT4 genes were expressed at a lower level in obese diabetic group compared to other groups and were statistically significant. PDK1 gene was expressed at a higher level in non-obese diabetic group compared to obese diabetic and non-obese non-diabetics groups. No statistically significant difference was identified in gene expression pattern of PI3K/AKT pathway between obese non-diabetics and non-obese non-diabetics. CONCLUSION: The components of PI3K/AKT pathway which is related to the fasting state, showed reduced expression in obese diabetic group due to the chronic over-nutrition which may induced insensitivity and reduced gene expression. The pathogenesis of insulin resistance in the absence of obesity in non-obese diabetic group could be due to disturbance in another pathway related to the non-fasting state like gluconeogenesis. Therefore, the molecular mechanism of insulin signalling in non-obese diabetic individuals is different from obese diabetics which more investigations are required to study insulin signalling pathways in greater depth, in order to assess nutritional factors, contribute to insulin resistance in obese diabetic and non-obese diabetic individuals. BioMed Central 2020-07-09 /pmc/articles/PMC7346329/ /pubmed/32670384 http://dx.doi.org/10.1186/s12986-020-00476-6 Text en © The Author(s) 2020 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research
Hosseini Khorami, Somayeh Alsadat
Mutalib, Mohd Sokhini Abd
Feili Shiraz, Mohammad
Abdullah, Joseph Anthony
Rejali, Zulida
Ali, Razana Mohd
Khaza’ai, Huzwah
Genetic determinants of obesity heterogeneity in type II diabetes
title Genetic determinants of obesity heterogeneity in type II diabetes
title_full Genetic determinants of obesity heterogeneity in type II diabetes
title_fullStr Genetic determinants of obesity heterogeneity in type II diabetes
title_full_unstemmed Genetic determinants of obesity heterogeneity in type II diabetes
title_short Genetic determinants of obesity heterogeneity in type II diabetes
title_sort genetic determinants of obesity heterogeneity in type ii diabetes
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7346329/
https://www.ncbi.nlm.nih.gov/pubmed/32670384
http://dx.doi.org/10.1186/s12986-020-00476-6
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