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Avian Metapneumovirus subtype B around Europe: a phylodynamic reconstruction
Avian Metapneumovirus (aMPV) has been recognized as a respiratory pathogen of turkey and chickens for a long time. Recently, a crescent awareness of aMPV, especially subtype B, clinical and economic impact has risen among European researchers and veterinarians. Nevertheless, the knowledge of its epi...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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BioMed Central
2020
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7346485/ https://www.ncbi.nlm.nih.gov/pubmed/32641149 http://dx.doi.org/10.1186/s13567-020-00817-6 |
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author | Franzo, Giovanni Legnardi, Matteo Mescolini, Giulia Tucciarone, Claudia Maria Lupini, Caterina Quaglia, Giulia Catelli, Elena Cecchinato, Mattia |
author_facet | Franzo, Giovanni Legnardi, Matteo Mescolini, Giulia Tucciarone, Claudia Maria Lupini, Caterina Quaglia, Giulia Catelli, Elena Cecchinato, Mattia |
author_sort | Franzo, Giovanni |
collection | PubMed |
description | Avian Metapneumovirus (aMPV) has been recognized as a respiratory pathogen of turkey and chickens for a long time. Recently, a crescent awareness of aMPV, especially subtype B, clinical and economic impact has risen among European researchers and veterinarians. Nevertheless, the knowledge of its epidemiology and evolution is still limited. In the present study, the broadest available collection of partial G gene sequences obtained from European aMPV-B strains was analyzed using different phylodynamic and biostatistical approaches to reconstruct the viral spreading over time and the role of different hosts on its evolution. After aMPV-B introduction, approximatively in 1985 in France, the infection spread was relatively quick, involving the Western and Mediterranean Europe until the end of the 1990s, and then spreading westwards at the beginning of the new millennium, in parallel with an increase of viral population size. In the following period, a wider mixing among aMPV-B strains detected in eastern and western countries could be observed. Most of the within-country genetic heterogeneity was ascribable to single or few introduction events, followed by local circulation. This, combined with the high evolutionary rate herein demonstrated, led to the establishment of genetically and phenotypically different clusters among countries, which could affect the efficacy of natural or vaccine-induced immunity and should be accounted for when planning control measure implementation. On the contrary, while a significant strain exchange was proven among turkey, guinea fowl and chicken, no evidence of differential selective pressures or specific amino-acid mutations was observed, suggesting that no host adaptation is occurring. |
format | Online Article Text |
id | pubmed-7346485 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-73464852020-07-14 Avian Metapneumovirus subtype B around Europe: a phylodynamic reconstruction Franzo, Giovanni Legnardi, Matteo Mescolini, Giulia Tucciarone, Claudia Maria Lupini, Caterina Quaglia, Giulia Catelli, Elena Cecchinato, Mattia Vet Res Research Article Avian Metapneumovirus (aMPV) has been recognized as a respiratory pathogen of turkey and chickens for a long time. Recently, a crescent awareness of aMPV, especially subtype B, clinical and economic impact has risen among European researchers and veterinarians. Nevertheless, the knowledge of its epidemiology and evolution is still limited. In the present study, the broadest available collection of partial G gene sequences obtained from European aMPV-B strains was analyzed using different phylodynamic and biostatistical approaches to reconstruct the viral spreading over time and the role of different hosts on its evolution. After aMPV-B introduction, approximatively in 1985 in France, the infection spread was relatively quick, involving the Western and Mediterranean Europe until the end of the 1990s, and then spreading westwards at the beginning of the new millennium, in parallel with an increase of viral population size. In the following period, a wider mixing among aMPV-B strains detected in eastern and western countries could be observed. Most of the within-country genetic heterogeneity was ascribable to single or few introduction events, followed by local circulation. This, combined with the high evolutionary rate herein demonstrated, led to the establishment of genetically and phenotypically different clusters among countries, which could affect the efficacy of natural or vaccine-induced immunity and should be accounted for when planning control measure implementation. On the contrary, while a significant strain exchange was proven among turkey, guinea fowl and chicken, no evidence of differential selective pressures or specific amino-acid mutations was observed, suggesting that no host adaptation is occurring. BioMed Central 2020-07-08 2020 /pmc/articles/PMC7346485/ /pubmed/32641149 http://dx.doi.org/10.1186/s13567-020-00817-6 Text en © The Author(s) 2020 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
spellingShingle | Research Article Franzo, Giovanni Legnardi, Matteo Mescolini, Giulia Tucciarone, Claudia Maria Lupini, Caterina Quaglia, Giulia Catelli, Elena Cecchinato, Mattia Avian Metapneumovirus subtype B around Europe: a phylodynamic reconstruction |
title | Avian Metapneumovirus subtype B around Europe: a phylodynamic reconstruction |
title_full | Avian Metapneumovirus subtype B around Europe: a phylodynamic reconstruction |
title_fullStr | Avian Metapneumovirus subtype B around Europe: a phylodynamic reconstruction |
title_full_unstemmed | Avian Metapneumovirus subtype B around Europe: a phylodynamic reconstruction |
title_short | Avian Metapneumovirus subtype B around Europe: a phylodynamic reconstruction |
title_sort | avian metapneumovirus subtype b around europe: a phylodynamic reconstruction |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7346485/ https://www.ncbi.nlm.nih.gov/pubmed/32641149 http://dx.doi.org/10.1186/s13567-020-00817-6 |
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