Cargando…

The MLH1 polymorphism rs1800734 and risk of endometrial cancer with microsatellite instability

Both colorectal (CRC, 15%) and endometrial cancers (EC, 30%) exhibit microsatellite instability (MSI) due to MLH1 hypermethylation and silencing. The MLH1 promoter polymorphism, rs1800734 is associated with MSI CRC risk, increased methylation and reduced MLH1 expression. In EC samples, we investigat...

Descripción completa

Detalles Bibliográficos
Autores principales:	Russell, Holly, Kedzierska, Katarzyna, Buchanan, Daniel D., Thomas, Rachael, Tham, Emma, Mints, Miriam, Keränen, Anne, Giles, Graham G., Southey, Melissa C., Milne, Roger L., Tomlinson, Ian, Church, David, Spurdle, Amanda B., O’Mara, Tracy A., Lewis, Annabelle
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2020
Materias:	Short Report
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7346630/ https://www.ncbi.nlm.nih.gov/pubmed/32641106 http://dx.doi.org/10.1186/s13148-020-00889-3

Ejemplares similares

Correction to: The MLH1 polymorphism rs1800734 and risk of endometrial cancer with microsatellite instability
por: Russell, Holly, et al.
Publicado: (2021)

The polymorphic variant rs1800734 influences methylation acquisition and allele-specific TFAP4 binding in the MLH1 promoter leading to differential mRNA expression
por: Thomas, Rachael, et al.
Publicado: (2019)

MLH1 rs1800734 Pathogenic Variant among Patients with Colorectal Cancer in the Lower Northeastern Region of Thailand
por: Pongsavee, Malinee, et al.
Publicado: (2023)

Expression of hMLH1 is inactivated in the gastric adenomas with enhanced microsatellite instability
por: Baek, M J, et al.
Publicado: (2001)

Microsatellite Instability and Altered Expressions of MLH1 and MSH2 in Gastric Cancer
por: Haron, Nor Hasyimah, et al.
Publicado: (2019)

Mlh1 heterozygosity and promoter methylation associates with microsatellite instability in mouse sperm
por: Shrestha, Kul S, et al.
Publicado: (2021)

Allele loss occurs frequently at hMLH1, but rarely at hMSH2, in sporadic colorectal cancers with microsatellite instability.
por: Tomlinson, I. P., et al.
Publicado: (1996)

Hypermethylation of the hMLH1 gene promoter in solitary and multiple gastric cancers with microsatellite instability
por: Sakata, K, et al.
Publicado: (2002)

The non-coding variant rs1800734 enhances DCLK3 expression through long-range interaction and promotes colorectal cancer progression
por: Liu, Ning Qing, et al.
Publicado: (2017)

Impact of BRAF, MLH1 on the incidence of microsatellite instability high colorectal cancer in populations based study
por: Brim, Hassan, et al.
Publicado: (2008)

Microsatellite Instability Use in Mismatch Repair Gene Sequence Variant Classification
por: Thompson, Bryony A., et al.
Publicado: (2015)

Microsatellite instability due to hMLH1 deficiency is associated with increased cytotoxicity to irinotecan in human colorectal cancer cell lines
por: Vilar, E, et al.
Publicado: (2008)

Mutational Analysis of Mismatch Repair Genes, hMLH1 and hMSH2, in Sporadic Endometrial Carcinomas with Microsatellite Instability
por: Kobayashi, Kanji, et al.
Publicado: (1996)

The dysfunctional Wnt pathway down-regulates MLH1/SET expression and promotes microsatellite instability and immunotherapy response in colorectal cancer
por: Wang, Jiyan, et al.
Publicado: (2023)

hMLH1 promoter methylation and BRAF mutations in high-frequency microsatellite instability colorectal cancers not fulfilling the revised Bethesda guidelines
por: Kim, Sang Jin, et al.
Publicado: (2014)

Editorial: Microsatellite and microsatellite instability
por: How-Kit, Alexandre, et al.
Publicado: (2023)

Mismatch Repair Proteins and Microsatellite Instability in Colorectal Carcinoma (MLH1, MSH2, MSH6 and PMS2): Histopathological and Immunohistochemical Study
por: Ismael, Nour El Hoda S., et al.
Publicado: (2017)

Mismatch Repair Genes Mlh1 and Mlh3 Modify CAG Instability in Huntington's Disease Mice: Genome-Wide and Candidate Approaches
por: Pinto, Ricardo Mouro, et al.
Publicado: (2013)

ARID1A genomic alterations driving microsatellite instability through somatic MLH1 methylation with response to immunotherapy in metastatic lung adenocarcinoma: a case report
por: Durán, Mercedes, et al.
Publicado: (2021)

The prognostic significance of microsatellite instability in colorectal cancer: a Swedish multi-center study
por: Rantanen, Petri, et al.
Publicado: (2023)

Colorectal tumour BRAF V600E and MLH1 promoter methylation status in the assessment of mismatch repair gene sequence variants of unknown clinical significance
por: Parsons, M, et al.
Publicado: (2012)

Combined Microsatellite Instability, MLH1 Methylation Analysis, and Immunohistochemistry for Lynch Syndrome Screening in Endometrial Cancers From GOG210: An NRG Oncology and Gynecologic Oncology Group Study
por: Goodfellow, Paul J., et al.
Publicado: (2015)

Microsatellite instability in ovarian neoplasms.
por: King, B. L., et al.
Publicado: (1995)

Microsatellite instability in colorectal cancer
por: Horvat, Matej, et al.
Publicado: (2011)

Microsatellite instability in colorectal cancer
por: Nojadeh, Jafar Nouri, et al.
Publicado: (2018)

Microsatellite instability in colorectal cancer
por: Gian, Luigi de’Angelis, et al.
Publicado: (2018)

Correlation of MLH1 and MGMT expression and promoter methylation with genomic instability in patients with thyroid carcinoma
por: Santos, Juliana Carvalho, et al.
Publicado: (2013)

Characterizing Microsatellite Instability and Chromosome Instability in Interval Colorectal Cancers
por: Cisyk, Amy L., et al.
Publicado: (2018)

Microsatellite instability in human prostate cancer.
por: Watanabe, M., et al.
Publicado: (1995)

No evidence of microsatellite instability in bone tumours.
por: Tarkkanen, M., et al.
Publicado: (1996)

Infrequent microsatellite instability in oesophageal cancers.
por: Muzeau, F., et al.
Publicado: (1997)

Microsatellite Instability in Sarcoma: Fact or Fiction?
por: Monument, Michael J., et al.
Publicado: (2012)

Lynch Syndrome (HNPCC) and Microsatellite Instability
por: Umar, Asad
Publicado: (2004)

Endometrial cancer and microsatellite instability status
por: Kanopiene, Daiva, et al.
Publicado: (2014)

Hypermutation and microsatellite instability in gastrointestinal cancers
por: Yuza, Kizuki, et al.
Publicado: (2017)

Microsatellite Instability in Medullary Carcinoma of the Colon
por: Martinotti, Mario, et al.
Publicado: (2017)

Microsatellite instability and chemosensitivity in solid tumours
por: Cherri, Sara, et al.
Publicado: (2022)

Medullary colonic carcinoma with microsatellite instability has lower survival compared with conventional colonic adenocarcinoma with microsatellite instability
por: Gómez-Álvarez, Miguel A., et al.
Publicado: (2016)

Isolated MLH1 Loss by Immunohistochemistry Because of Benign Germline MLH1 Polymorphisms
por: Bosch, Dustin E., et al.
Publicado: (2022)

Microsatellite instability in early sporadic breast cancer.
por: Shaw, J. A., et al.
Publicado: (1996)

Cannot write session to /tmp/vufind_sessions/sess_ptdhstoj6ugg5mflfnk4t0i81m