The divergence between SARS-CoV-2 and RaTG13 might be overestimated due to the extensive RNA modification

Aim: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has spread throughout the world. There is urgent need to understand the phylogeny, divergence and origin of SARS-CoV-2. Materials & methods: A recent study claimed that there was 17% divergence between SARS-CoV-2 and RaTG13 (a SAR...

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Autores principales: Li, Yue, Yang, Xinai, Wang, Na, Wang, Haiyan, Yin, Bin, Yang, Xiaoping, Jiang, Wenqing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Future Medicine Ltd 2020
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7346715/
http://dx.doi.org/10.2217/fvl-2020-0066
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author Li, Yue
Yang, Xinai
Wang, Na
Wang, Haiyan
Yin, Bin
Yang, Xiaoping
Jiang, Wenqing
author_facet Li, Yue
Yang, Xinai
Wang, Na
Wang, Haiyan
Yin, Bin
Yang, Xiaoping
Jiang, Wenqing
author_sort Li, Yue
collection PubMed
description Aim: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has spread throughout the world. There is urgent need to understand the phylogeny, divergence and origin of SARS-CoV-2. Materials & methods: A recent study claimed that there was 17% divergence between SARS-CoV-2 and RaTG13 (a SARS-related coronaviruses) on synonymous sites by using sequence alignment. We re-analyzed the sequences of the two coronaviruses with the same methodology. Results: We found that 87% of the synonymous substitutions between the two coronaviruses could be potentially explained by the RNA modification system in hosts, with 65% contributed by deamination on cytidines (C-T mismatches) and 22% contributed by deamination on adenosines (A-G mismatches). Conclusion: Our results demonstrate that the divergence between SARS-CoV-2 and RaTG13 has been overestimated.
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spelling pubmed-73467152020-07-09 The divergence between SARS-CoV-2 and RaTG13 might be overestimated due to the extensive RNA modification Li, Yue Yang, Xinai Wang, Na Wang, Haiyan Yin, Bin Yang, Xiaoping Jiang, Wenqing Future Virol Short Communication Aim: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has spread throughout the world. There is urgent need to understand the phylogeny, divergence and origin of SARS-CoV-2. Materials & methods: A recent study claimed that there was 17% divergence between SARS-CoV-2 and RaTG13 (a SARS-related coronaviruses) on synonymous sites by using sequence alignment. We re-analyzed the sequences of the two coronaviruses with the same methodology. Results: We found that 87% of the synonymous substitutions between the two coronaviruses could be potentially explained by the RNA modification system in hosts, with 65% contributed by deamination on cytidines (C-T mismatches) and 22% contributed by deamination on adenosines (A-G mismatches). Conclusion: Our results demonstrate that the divergence between SARS-CoV-2 and RaTG13 has been overestimated. Future Medicine Ltd 2020-03-24 2020-04 /pmc/articles/PMC7346715/ http://dx.doi.org/10.2217/fvl-2020-0066 Text en © 2020 Future Medicine Ltd This work is licensed under the Creative Commons Attribution 4.0 License (http://creativecommons.org/licenses/by/4.0/)
spellingShingle Short Communication
Li, Yue
Yang, Xinai
Wang, Na
Wang, Haiyan
Yin, Bin
Yang, Xiaoping
Jiang, Wenqing
The divergence between SARS-CoV-2 and RaTG13 might be overestimated due to the extensive RNA modification
title The divergence between SARS-CoV-2 and RaTG13 might be overestimated due to the extensive RNA modification
title_full The divergence between SARS-CoV-2 and RaTG13 might be overestimated due to the extensive RNA modification
title_fullStr The divergence between SARS-CoV-2 and RaTG13 might be overestimated due to the extensive RNA modification
title_full_unstemmed The divergence between SARS-CoV-2 and RaTG13 might be overestimated due to the extensive RNA modification
title_short The divergence between SARS-CoV-2 and RaTG13 might be overestimated due to the extensive RNA modification
title_sort divergence between sars-cov-2 and ratg13 might be overestimated due to the extensive rna modification
topic Short Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7346715/
http://dx.doi.org/10.2217/fvl-2020-0066
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