Wnt regulation: exploring Axin-Disheveled interactions and defining mechanisms by which the SCF E3 ubiquitin ligase is recruited to the destruction complex

Wnt signaling plays key roles in embryonic development and adult stem cell homeostasis and is altered in human cancer. Signaling is turned on and off by regulating stability of the effector β-catenin (β-cat). The multiprotein destruction complex binds and phosphorylates β-cat and transfers it to the...

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Detalles Bibliográficos
Autores principales: Schaefer, Kristina N., Pronobis, Mira I., Williams, Clara E., Zhang, Shiping, Bauer, Lauren, Goldfarb, Dennis, Yan, Feng, Major, M. Ben, Peifer, Mark
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The American Society for Cell Biology 2020
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7346726/
https://www.ncbi.nlm.nih.gov/pubmed/32129710
http://dx.doi.org/10.1091/mbc.E19-11-0647

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7346726/
https://www.ncbi.nlm.nih.gov/pubmed/32129710
http://dx.doi.org/10.1091/mbc.E19-11-0647

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