Human Virus Transcriptional Regulators

Viral genomes encode transcriptional regulators that alter the expression of viral and host genes. Despite an emerging role in human diseases, a thorough annotation of human viral transcriptional regulators (vTRs) is currently lacking, limiting our understanding of their molecular features and funct...

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Detalles Bibliográficos
Autores principales: Liu, Xing, Hong, Ted, Parameswaran, Sreeja, Ernst, Kevin, Marazzi, Ivan, Weirauch, Matthew T., Fuxman Bass, Juan I.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Inc. 2020
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7346790/
https://www.ncbi.nlm.nih.gov/pubmed/32649876
http://dx.doi.org/10.1016/j.cell.2020.06.023
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author Liu, Xing
Hong, Ted
Parameswaran, Sreeja
Ernst, Kevin
Marazzi, Ivan
Weirauch, Matthew T.
Fuxman Bass, Juan I.
author_facet Liu, Xing
Hong, Ted
Parameswaran, Sreeja
Ernst, Kevin
Marazzi, Ivan
Weirauch, Matthew T.
Fuxman Bass, Juan I.
author_sort Liu, Xing
collection PubMed
description Viral genomes encode transcriptional regulators that alter the expression of viral and host genes. Despite an emerging role in human diseases, a thorough annotation of human viral transcriptional regulators (vTRs) is currently lacking, limiting our understanding of their molecular features and functions. Here, we provide a comprehensive catalog of 419 vTRs belonging to 20 different virus families. Using this catalog, we characterize shared and unique cellular genes, proteins, and pathways targeted by particular vTRs and discuss the role of vTRs in human disease pathogenesis. Our study provides a unique and valuable resource for the fields of virology, genomics, and human disease genetics.
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spelling pubmed-73467902020-07-10 Human Virus Transcriptional Regulators Liu, Xing Hong, Ted Parameswaran, Sreeja Ernst, Kevin Marazzi, Ivan Weirauch, Matthew T. Fuxman Bass, Juan I. Cell Review Viral genomes encode transcriptional regulators that alter the expression of viral and host genes. Despite an emerging role in human diseases, a thorough annotation of human viral transcriptional regulators (vTRs) is currently lacking, limiting our understanding of their molecular features and functions. Here, we provide a comprehensive catalog of 419 vTRs belonging to 20 different virus families. Using this catalog, we characterize shared and unique cellular genes, proteins, and pathways targeted by particular vTRs and discuss the role of vTRs in human disease pathogenesis. Our study provides a unique and valuable resource for the fields of virology, genomics, and human disease genetics. Elsevier Inc. 2020-07-09 2020-07-09 /pmc/articles/PMC7346790/ /pubmed/32649876 http://dx.doi.org/10.1016/j.cell.2020.06.023 Text en © 2020 Elsevier Inc. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Review
Liu, Xing
Hong, Ted
Parameswaran, Sreeja
Ernst, Kevin
Marazzi, Ivan
Weirauch, Matthew T.
Fuxman Bass, Juan I.
Human Virus Transcriptional Regulators
title Human Virus Transcriptional Regulators
title_full Human Virus Transcriptional Regulators
title_fullStr Human Virus Transcriptional Regulators
title_full_unstemmed Human Virus Transcriptional Regulators
title_short Human Virus Transcriptional Regulators
title_sort human virus transcriptional regulators
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7346790/
https://www.ncbi.nlm.nih.gov/pubmed/32649876
http://dx.doi.org/10.1016/j.cell.2020.06.023
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